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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Fibroblast growth factor-2 alters the effect of eroding polylactide-polyglycolide on osteogenesis in the bone chamber.
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Fibroblast growth factor-2 alters the effect of eroding polylactide-polyglycolide on osteogenesis in the bone chamber.

机译：成纤维细胞生长因子2改变侵蚀的聚丙交酯-聚乙交酯对骨腔中成骨的影响。

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摘要

The effects of recombinant human fibroblast growth factor-2 (rhFGF-2) in the presence of eroding 50:50 poly(DL-lactide-co-glycolide) (PDLLG) on acute bone healing were studied in the optical bone chamber (BCI). BCIs were loaded with disks of PDLLG surrounded by one of four rhFGF-2 doses. Fifty-two female rabbit right tibias were implanted. Commencing the third week post implantation (W3) healing in the BCI compartment was observed weekly, using intravital microscopy, until W8. The doses were: unloaded, loaded with polymer only, and polymer plus 0.5, 1.0, and 10 microg rhFGF-2. Videotaped and photographed bone images were measured and analyzed using a frame-grabber digitizing system. Comparison with controls revealed that ossification rates were significantly above normal in rabbits loaded with polymer plus any of the rhFGF-2 doses. Comparison with polymer-only BCIs showed that PDLLG plus any of the three rhFGF-2 doses was linked with ossification rates significantly higher than baseline. The results indicated that FGF-2 in the dose range studied effectively can overcome the retarding effects of eroding polymer on ossification that has been reported by this laboratory. Interpretation of the retarding effects of the polymer disks, although consistent with previously studied washer-shaped devices of the same material, was complicated by a difference in erosion rate. This result supports the notion that erodible device geometry is a major factor in determining biocompatibility and must be considered in the design of carriers. Accordingly, programming of dose specificity for delivering a given polypeptide cytokine to a given host site must allow for the inhibitory effects of an eroding carrier and the influence of device geometry on these effects and erosion.
机译：在光学骨腔（BCI）中研究了在50:50聚（DL-丙交酯-共-乙交酯）侵蚀的重组人成纤维细胞生长因子2（rhFGF-2）对急性骨愈合的影响。 。 BCI装有PDLLG盘，被四个rhFGF-2剂量之一包围。植入52只雌性兔右胫骨。每周观察一次植入后第三周（W3），使用活体显微镜观察BCI腔室的愈合情况，直到W8。剂量为：卸载，仅加载聚合物，以及聚合物加0.5、1.0和10 microg rhFGF-2。使用帧采集器数字化系统对录像和拍摄的骨骼图像进行测量和分析。与对照的比较显示，在加载了聚合物和任何rhFGF-2剂量的兔子中，骨化率明显高于正常水平。与仅聚合物的BCI的比较显示，PDLLG加上三种rhFGF-2剂量中的任何一种都与骨化率显着高于基线有关。结果表明，在所研究的剂量范围内，FGF-2能有效克服该实验室报道的侵蚀聚合物对骨化的阻滞作用。尽管与先前研究的相同材料的垫圈形装置相一致，但对聚合物圆盘的阻滞作用的解释却因腐蚀速率的不同而变得复杂。该结果支持这样一种观念，即易蚀设备的几何形状是决定生物相容性的主要因素，必须在载体设计中予以考虑。因此，用于将给定多肽细胞因子递送至给定宿主位点的剂量特异性的编程必须考虑到侵蚀性载体的抑制作用以及装置几何形状对这些作用和腐蚀的影响。

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