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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Influence of hernioplastic implants on male fertility in rats.
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Influence of hernioplastic implants on male fertility in rats.

机译：疝成形术植入物对大鼠雄性生殖的影响。

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摘要

This study explored the vulnerability of the ductus deferens due to mesh induced inflammation and shrinkage after hernia repair in the rodent model. Two commonly used types of hernioplastic implants (Prolene and Vypro II) were surgically wrapped around the ductus deferentes on both sides in 20 juvenile and 20 adult Sprague-Dawley rats. Twenty male rats underwent sham surgeries as controls. After 3 months, each male was mated with 2-3 adult females, which were subsequently sacrificed and oocytes or embryos were flushed and counted. Histochemical investigations of the implants and the ductus recovered surgically 4 weeks after implantation (one side) and after the fertility test (second side) were conducted. All groups exhibited 1-3 males with decreased or restricted fertility but there was no difference between groups. Histochemical analysis of the implants and the ductus recovered 4 weeks and 4 months after implantation revealed some sperm granulomes due to lesions of the spermatic cord caused by the implant in the Prolene group. There was no inflammatory reaction in the mucosa or blockage of the spermatic cord visible. Both types of hernioplastic implants tested in this investigation do not give an indication of a negative influence on male fertility in juvenile or adult rats.
机译：这项研究探讨了在啮齿动物模型中疝修补后网孔引起的炎症和萎缩引起的输精管的脆弱性。在20只幼年和20只成年Sprague-Dawley大鼠中，将两种常用类型的增生塑料植入物（Prolene和Vypro II）通过手术包裹在两侧的输精管周围。二十只雄性大鼠接受假手术作为对照。 3个月后，将每只雄性与2-3只成年雌性交配，随后将其处死并冲洗卵母细胞或胚胎并计数。对植入物和导管的组织化学研究在植入后4周（一侧）和在进行生育力测试（第二侧）后进行了手术。所有组均显示1-3名男性生殖力下降或受限制，但两组之间无差异。对植入物和导管的组织化学分析在植入后4周和4个月恢复，发现Prolene组中的一些精子颗粒是由于植入物引起的精索损伤所致。粘膜无炎症反应或可见精索阻塞。在这项研究中测试的两种类型的增塑剂植入物均未显示出对幼年或成年大鼠的雄性生育能力有负面影响的迹象。

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