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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Influence of Mixing Method on the Cement Temperature-Mixing Time History and Doughing Time of Three Acrylic Cements for Vertebroplasty
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Influence of Mixing Method on the Cement Temperature-Mixing Time History and Doughing Time of Three Acrylic Cements for Vertebroplasty

机译：混合方法对三种丙烯酸骨水泥椎体成形术水泥温度混合时间历程和生面团时间的影响

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摘要

Acrylic cements are increasingly being used to augment osteoporotic vertebrae in a procedure called vertebroplasty. Two significant factors that may complicate the use of acrylic cements are: (a) short handling time, which may result in insufficient filling of the vertebra; and (b) exothermic setting (curing) behavior, which may result in thermal damage of the surrounding tissue. It has been previously reported that mixing the cement components under oscillation, as compared to manual mixing, increases the handling time. More specifically, it seems that oscillatory mixing slows down the cement polymerization process and, consequently, widens the time window during which cement is injectable. However, the effect of oscillatory mixing on the exothermic setting behavior of cement undergoing polymerization has not been examined. In this study, the exothermic setting behavior of three commercially available acrylic cements- Antibiotic Simplex~R, DP-Pour&trade, and Vertebroplastic~(TM)-were examined for both manual and oscillatory mixing methods. For each combination of cement and mixing method, the parameters that were measured were the exothermic setting curve (and hence the cement setting temperature and setting time) and the cement doughing time. It was found that oscillatory mixing had no significant effect on any of these parameters. Based on the results of this study, it can be concluded that, for the tested cements, the setting process is a reaction-controlled process rather than a diffusion-controlled one. Clinically, this implies that oscillatory mixing may be used to increase the working period for acrylic cements without increasing the risk of thermal damage to surrounding tissue.
机译：在称为椎体成形术的过程中，越来越多地使用丙烯酸水泥来增加骨质疏松性椎骨。可能会使丙烯酸水泥的使用变得复杂的两个重要因素是：（a）处理时间短，可能导致椎骨填充不足; （b）放热定型（固化）行为，可能导致周围组织的热损伤。先前已经报道，与手动混合相比，在振荡下混合水泥组分会增加处理时间。更具体地说，似乎振荡混合减慢了水泥的聚合过程，因此，加宽了可注入水泥的时间窗口。然而，尚未检查振荡混合对经历聚合反应的水泥的放热凝固行为的影响。在这项研究中，对三种市售丙烯酸胶粘剂-抗生素Simplex®R，DP-Pour＆trade和Vertebroplastic®（TM）的放热凝固行为进行了手动和振荡混合方法的研究。对于水泥和混合方法的每种组合，所测量的参数是放热凝固曲线（以及水泥凝固温度和凝固时间）和水泥生面团时间。发现振荡混合对这些参数中的任何一个都没有显着影响。根据这项研究的结果，可以得出结论，对于测试的水泥，凝结过程是反应控制的过程，而不是扩散控制的过程。临床上，这意味着振荡混合可用于增加丙烯酸水泥的工作时间，而不会增加对周围组织造成热损伤的风险。

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