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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >Intra-articular calcium phosphate cement: Its fate and impact on joint tissues in a rabbit model.
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Intra-articular calcium phosphate cement: Its fate and impact on joint tissues in a rabbit model.

机译：关节内磷酸钙水泥：在兔模型中其命运和对关节组织的影响。

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摘要

Clinical application of injectable ceramic cement in comminuted fractures revealed penetration of the viscous paste into the joint space. Not much is known on the fate of this cement and its influence on articular tissues. The purpose of this experimental study was to assess these unknown alterations of joint tissues after intra-articular injection of cement in a rabbit knee. Observation periods were from 1 week up to 24 months, with three rabbits per group. Norian SRS cement was injected into one knee joint, the contralateral side receiving the same volume of Ringers' solution. Light microscopic evaluation of histologic sections was performed, investigating the appearance of the cement, inflammatory reactions, and degenerative changes of the articular surface. No signs of pronounced acute or chronic inflammation were visible. The injected cement was mainly found as a single particle, anterior to the cruciate ligaments. It became surrounded by synovial tissues within 4 weeks and showed signs of superficial resorption. In some specimens, bone formation was seen around the cement. Degeneration of the articular surface showed no differences between experimental and control side, and no changes over time became apparent. No major degenerative changes were induced by the injected cement. The prolonged presence of cement still seems to make it advisable to remove radiologically visible amounts from the joint space.
机译：可注射陶瓷胶粘剂在粉碎性骨折中的临床应用表明粘性糊剂渗透到关节间隙中。关于这种水泥的结局及其对关节组织的影响知之甚少。本实验研究的目的是评估兔膝关节内注射水泥后关节组织的这些未知变化。观察期为1周至24个月，每组三只兔子。将Norian SRS水泥注入一个膝关节，对侧接受相同体积的林格氏液。对组织切片进行光学显微镜评估，研究了水泥的外观，炎症反应以及关节表面的退行性变化。没有明显的急性或慢性炎症迹象。注入的水泥主要被发现为单个颗粒，位于十字韧带之前。在4周内被滑膜组织包围，并显示出表面吸收的迹象。在一些标本中，在水泥周围可见骨形成。关节表面的变性显示实验侧和对照侧之间没有差异，并且随时间的变化也没有明显。注入的水泥没有引起主要的退化变化。长期存在水泥似乎仍然建议从关节腔中清除放射学上可见的量。

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