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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels.
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In vitro and in vivo degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels.

机译：聚（富马酸丙二醇酯-共-乙二醇）水凝胶的体外和体内降解。

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The degradation of poly(propylene fumarate-co-ethylene glycol) hydrogels was examined in vitro in phosphate-buffered saline at pH 7.4 and in vivo in a subcutaneous rat model. These hydrogels have potential application as biodegradable, injectable cardiovascular stents, and, as such, their mass loss, dimensional changes, mechanical properties, morphology, and biocompatibility over a 12-week time course were evaluated. Three formulations were fabricated: one base formulation consisting of 25% (w/w) PEG, molecular weight 4,600; one high weight percent PEG formulation with 50% (w/w) PEG; and one high molecular weight PEG formulation, molecular weight 10,500. All three formulations showed significant weight loss (between 40 and 60%) on the first day due to leaching of the uncrosslinked fraction. Further weight loss was observed only for the low weight percent PEG copolymers in the in vivo case, and a slight increase in volume was observed due to degradative swelling. The mechanical properties of the P(PF-co-EG) hydrogels decreased significantly in the first 3 weeks, showing the biphasic pattern typical of bulk degradation. In vitro, the hydrogels showed at least a 20% retention of their initial ultimate tensile stress after 3 weeks. The dynamic mechanical properties showed similar retention, with the in vivo mechanical properties differing from the in vitro properties only after 6 weeks of degradation. Differences in PEG molecular weight appeared to have little effect, but increasing the weight percent PEG decreased the rate of degradation both in vitro and in vivo. The morphology of the copolymer films, based on scanning electron microscopy observation, was not significantly different either among the three formulations or over the time course of the study, suggesting there were no macroscopic structural changes during this time period. The P(PF-co-EG) hydrogels demonstrated good initial biocompatibility, showing responses characteristic of biomaterial implants.
机译：在pH 7.4的磷酸盐缓冲盐水中体外和在皮下大鼠模型中检查了聚（富马酸丙二醇酯-共-乙二醇）水凝胶的降解。这些水凝胶具有可生物降解，可注射的心血管支架的潜在应用，因此，评估了它们在12周时间内的质量损失，尺寸变化，机械性能，形态和生物相容性。制造了三种制剂：一种由25％（w / w）PEG组成，分子量4,600的基础制剂;一种具有50％（w / w）PEG的高重量百分比PEG制剂;一种高分子量PEG制剂，分子量为10,500。由于未交联部分的浸出，所有三种制剂在第一天都显示出显着的重量减轻（40％至60％）。在体内情况下，仅对于低重量百分比的PEG共聚物观察到进一步的重量损失，并且由于降解溶胀而观察到体积略有增加。 P（PF-co-EG）水凝胶的机械性能在开始的三周内显着下降，显示出批量降解的典型两相模式。在体外，水凝胶在3周后显示出其初始极限拉伸应力至少20％的保留率。动态机械性能显示出相似的保留，仅在降解6周后体内机械性能与体外性能不同。 PEG分子量的差异似乎影响很小，但是增加PEG的重量百分数会降低体外和体内的降解速率。基于扫描电子显微镜观察，共聚物膜的形态在三种配方之间或整个研究过程中均无显着差异，表明在这段时间内没有宏观的结构变化。 P（PF-co-EG）水凝胶表现出良好的初始生物相容性，显示出生物材料植入物的响应特征。

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