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首页> 外文期刊>Journal of bone and mineral metabolism >Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study
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Evaluating spine micro-architectural texture (via TBS) discriminates major osteoporotic fractures from controls both as well as and independent of site matched BMD: the Eastern European TBS study

机译：通过TBS评估脊柱的微结构质地，可以将主要骨质疏松性骨折与对照组以及与部位匹配的BMD区别开来：东欧TBS研究

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摘要

The aim of the study was to assess the clinical performance of the model combining areal bone mineral density (aBMD) at spine and microarchitecural texture (TBS) for the detection of the osteoporotic fracture. The Eastern European Study is a multicenter study (Serbia, Bulgaria, Romania and Ukraine) evaluating the role of TBS in routine clinical practice as a complement to aBMD. All scans were acquired on Hologic Discovery and GE Prodigy densitometers in a routine clinical manner. The additional clinical values of aBMD and TBS were analyzed using a two steps classification tree approach (aBMD followed by TBS textiles) for all type of osteoporotic fracture (All-OP Fx). Sensitivity, specificity and accuracy of fracture detection as well as the Net Reclassification Index (NRI) were calculated. This study involves 1031 women subjects aged 45 and older recruited in east European countries. Clinical centers were cross-calibrated in terms of BMD and TBS. As expected, areal BMD (aBMD) at spine and TBS were only moderately correlated (r2 = 0.19). Prevalence rate for All-OP Fx was 26 %.
机译：这项研究的目的是评估该模型在脊柱处的面骨矿物质密度（aBMD）和微建筑壁纹理（TBS）的临床性能，以检测骨质疏松性骨折。东欧研究是一项多中心研究（塞尔维亚，保加利亚，罗马尼亚和乌克兰），评估TBS在常规临床实践中作为aBMD的补充的作用。所有扫描均以常规临床方式在Hologic Discovery和GE Prodigy密度计上进行。对于所有类型的骨质疏松性骨折（All-OP Fx），使用两步分类树方法（aBMD，然后是TBS纺织品）分析了aBMD和TBS的其他临床价值。计算了裂缝检测的敏感性，特异性和准确性，以及净重分类指数（NRI）。这项研究涉及东欧国家招募的1031名年龄在45岁及以上的女性受试者。临床中心根据BMD和TBS进行了交叉校准。正如预期的那样，脊柱和TBS处的区域BMD（aBMD）仅具有中等相关性（r2 = 0.19）。 All-OP Fx的患病率为26％。

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