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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Making rats rise to erect bipedal stance for feeding partially prevented orchidectomy-induced bone loss and added bone to intact rats.
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Making rats rise to erect bipedal stance for feeding partially prevented orchidectomy-induced bone loss and added bone to intact rats.

机译：使大鼠升起直立的两足动物姿势来进食可以部分地防止兰花切除术引起的骨质流失，并为完整的大鼠增加骨骼。

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The objectives of this study were to investigate the different effects on muscle mass and cancellous (proximal tibial metaphysis [PTM]) and cortical (tibial shaft [TX]) bone mass of sham-operated and orchidectomized (ORX) male rats by making rats rise to erect bipedal stance for feeding. Specially designed raised cages (RC) were used so that the rats had to rise to erect bipedal stance to eat and drink for 12 weeks. Dual-energy X-ray absorptiometry (DEXA) and peripheral quantitative computerized tomography (pQCT) were used to estimate the lean leg mass and bone mineral. Static and dynamic histomorphometry were performed on the triple-labeled undecalcified sections. We found that making the intact rats rise to erect bipedal stance for feeding increased muscle mass, cortical bone volume, and periosteal bone formation. Orchidectomy increased net losses of bone next to the marrow by increasing bone turnover. Making the ORX rats rise to erect bipedal stance increased muscle mass, partially prevented cancellous bone loss in the PTM, and prevented net cortical bone loss in TX induced by ORX by depressing cancellous and endocortical high bone turnover and stimulating periosteal bone formation. The bone-anabolic effects were achieved mainly in the first 4 weeks in the PTM and by 8 weeks in the TX. These findings suggested that making the rats rise to erect bipedal stance for feeding helped to increase muscle mass and cortical bone mass in the tibias of intact rats, increase muscle mass, and partially prevented cancellous and net cortical bone loss in ORX rats.
机译：这项研究的目的是通过使大鼠抬高，研究假手术和睾丸切除术（ORX）雄性大鼠对肌肉质量和松质（胫骨干physi端[PTM]）和皮质（胫骨干[TX]）骨量的不同影响竖立两足动物的进食姿势。使用经过特殊设计的高架笼子（RC），这样老鼠必须站起来以竖立两足动物的姿势才能进食12周。双能X线骨密度仪（DEXA）和外围定量计算机断层扫描（pQCT）用于估算瘦腿质量和骨矿物质。静态和动态组织形态计量学在三重标记的未脱钙切片上进行。我们发现使完整的大鼠上升到直立的两足动物姿势，以喂养增加的肌肉质量，皮质骨量和骨膜骨形成。睾丸切除术通过增加骨骼更新来增加骨髓旁的骨骼净损失。使ORX大鼠上升到直立的双足姿势，增加了肌肉质量，部分地阻止了PTM中的松质骨丢失，并通过抑制松质和皮质内高骨转换和刺激骨膜形成，防止了ORX诱导的TX净皮质骨丢失。骨合成代谢作用主要在PTM的前4周和TX的8周获得。这些发现表明，使大鼠上升为直立的两足动物站立姿势，有助于增加完整大鼠胫骨的肌肉质量和皮质骨质量，增加肌肉质量，并部分预防ORX大鼠松质和净皮质骨丢失。

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