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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Molecular genetic studies of gene identification for osteoporosis: a 2004 update.
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Molecular genetic studies of gene identification for osteoporosis: a 2004 update.

机译：骨质疏松症基因鉴定的分子遗传学研究：2004年更新。

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摘要

This review summarizes comprehensively the most important and representative molecular genetics studies of gene identification for osteoporosis published up to the end of December 2004. It is intended to constitute a sequential update of our previously published review covering the available data up to the end of 2002. Evidence from candidate gene association studies and genome-wide linkage studies in humans, as well as quantitative trait locus mapping animal models are reviewed separately. Studies of transgenic and knockout mice models relevant to osteoporosis are summarized. An important extension of this update is incorporation of functional genomic studies (including DNA microarrays and proteomics) on osteogenesis and osteoporosis, in light of the rapid advances and the promising prospects of the field. Comments are made on the most notable findings and representative studies for their potential influence and implications on our present understanding of genetics of osteoporosis. The format adopted by this review should be ideal for accommodating future new advances and studies.
机译：这篇综述全面总结了截至2004年12月底发表的有关骨质疏松症基因鉴定的最重要和最具代表性的分子遗传学研究。它旨在构成我们先前发表的综述的序贯更新，其中涵盖了2002年底之前的可用数据。分别审查了来自候选基因关联研究和人类全基因组连锁研究以及定量性状基因座作图动物模型的证据。总结了与骨质疏松症相关的转基因和基因敲除小鼠模型的研究。考虑到该领域的快速发展和广阔前景，该更新的重要扩展是纳入了有关成骨和骨质疏松的功能基因组研究（包括DNA芯片和蛋白质组学）。评论对最显着的发现和代表性研究的潜在影响和对我们目前对骨质疏松症遗传学的理解的潜在影响。这次审查采用的格式应该是适应未来新进展和研究的理想选择。

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