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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice.
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Osteoprotegerin abrogates chronic alcohol ingestion-induced bone loss in mice.

机译：骨保护素消除了小鼠长期饮酒引起的骨质流失。

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摘要

To investigate the role of osteoprotegerin (OPG) on alcohol (ethanol)-mediated osteoporosis, we measured a variety of bone remodeling parameters in mice that were either on a control diet, an ethanol (5%) diet, or an ethanol (5%) diet plus OPG administration. OPG diminished the ethanol-induced (1) decrease in bone mineral density (BMD) as determined by dual-energy densitometry, (2) decrease in cancellous bone volume and trabecular width and the increase of osteoclast surface as determined by histomorphometry of the femur, (3) increase in urinary deoxypyridinolines (Dpd's) as determined by ELISA, and (4) increase in colony-forming unit-granulocyte macrophage (CFU-GM) formation and osteoclastogenesis as determined by ex vivo bone marrow cell cultures. Additionally, OPG diminished the ethanol-induced decrease of several osteoblastic parameters including osteoblast formation and osteoblast culture calcium retention. These findings were supported by histomorphometric indices in the distal femur. Taken together, these data show that OPG diminishes ethanol-induced bone loss. Furthermore, they suggest that OPG achieves this through its ability to abrogate ethanol-induced promotion of osteoclastogenesis and promote osteoblast proliferation.
机译：为了研究骨保护素（OPG）在酒精（乙醇）介导的骨质疏松症中的作用，我们测量了对照饮食，乙醇（5％）饮食或乙醇（5％）的小鼠的各种骨骼重塑参数）饮食加OPG给药。 OPG减少了乙醇诱导的（1）通过双能量密度测定法确定的骨矿物质密度（BMD）的降低;（2）通过股骨的组织形态测定法确定的松质骨体积和小梁宽度的减少以及破骨细胞表面的增加， （3）通过ELISA确定尿中的脱氧吡啶并啉（Dpd's）增加，以及（4）通过离体骨髓细胞培养确定的菌落形成单位-粒细胞巨噬细胞（CFU-GM）形成和破骨细胞生成增加。另外，OPG减少了乙醇诱导的几个成骨细胞参数的降低，包括成骨细胞形成和成骨细胞培养物钙保留。这些发现得到了股骨远端组织形态计量学指数的支持。综上，这些数据表明OPG减少了乙醇引起的骨质流失。此外，他们建议OPG通过消除乙醇诱导的破骨细胞形成促进和成骨细胞增殖的能力来实现这一目标。

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