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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men.
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Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men.

机译：美国老年男性股骨近端的尺寸和体积BMD及其与年龄的关系。

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摘要

We measured femoral neck and shaft dimensions and volumetric BMD with QCT. Relations of these measures to age were quantified in a cross-sectional study among 3358 men 65-100 years old. Relations of femoral neck dimensions and vBMD to age differed from those in the shaft, indicating that patterns of bone modeling and remodeling in the neck and shaft are distinct. INTRODUCTION: Little is known about population variation in dimensions and volumetric BMD of the proximal femur or the relation of these measures to age among older men. MATERIALS AND METHODS: In a cross-sectional study, dimensions and volumetric BMD (vBMD) in the femoral neck and shaft were obtained from QCT scans among 3358 men 65-100 years of age in the Osteoporotic Fractures in Men cohort. Total bone size and size of the cortical and medullary compartments were measured with volumes in the femoral neck and with areas in the shaft. We quantified distributions of these measures and examined their relations to age with multivariable linear regression. RESULTS: Population variation in femoral neck and shaft dimensions and vBMD was substantial. In the femoral neck, total volume was minimally related to age, whereas cortical volume was 5% smaller and medullary volume was 10% larger (both p < 0.0001) in the oldest (85+ years) compared with the youngest (65-69 years) men. Across these ages, the percent of cortical bone declined from 46% to 42% (p < 0.0001). Integral and trabecular vBMD were 9% and 22% lower, whereas DXA femoral neck BMD was 4% lower, in the older men. Neck cortical vBMD was unrelated to age. In the shaft, cross-sectional area and medullary area were 9% and 22% larger, respectively, in the oldest men (both p < 0.0001), but cortical area was unchanged with age. The percent of cortical bone declined from 69% to 65% across these ages (p < 0.0001). Shaft cortical BMD was 4% lower in the older men (p < 0.0001). CONCLUSIONS: There is substantial diversity of femoral morphology and vBMD among older U.S. men. Patterns indicative of modeling and remodeling in the femoral neck were distinct from those in the shaft. Notably, changes in periosteal and endosteal dimensions that underlie cortical thinning appear to differ in the neck and shaft.
机译：我们用QCT测量了股骨颈和干轴的尺寸以及BMD的体积。在一项横断面研究中，对3358名65至100岁的男性进行了量化，以量化这些指标与年龄之间的关系。股骨颈尺寸和vBMD与年龄之间的关系与杆身中的关系不同，这表明在颈部和杆身中骨骼建模和重塑的模式不同。简介：对于年龄较大的男性，股骨近端的尺寸和体积BMD的人口变化或这些指标与年龄的关系知之甚少。材料与方法：在一项横断面研究中，通过对3358名年龄在100至100岁之间的男性骨质疏松性骨折的男性进行QCT扫描，获得了股骨颈和骨干的尺寸和体积BMD（vBMD）。用股骨颈中的体积和轴中的面积测量骨的总大小以及皮质和髓腔的大小。我们量化了这些量度的分布，并通过多元线性回归检验了它们与年龄的关系。结果：股骨颈和轴的尺寸和vBMD的人群差异很大。与年龄最小的（65-69岁）相比，年龄最大的（85岁以上）的股骨颈与年龄的相关性最小，而皮质的体积小5％，而髓质的体积大10％（均p <0.0001）。 ）男人。在这些年龄段，皮质骨的百分比从46％下降至42％（p <0.0001）。在老年男性中，整体和小梁vBMD分别降低了9％和22％，而DXA股骨颈BMD降低了4％。颈部皮质vBMD与年龄无关。在骨干中，年龄最大的男性（均p <0.0001）的截面积和髓质面积分别大9％和22％，但皮质区域随年龄而不变。在这些年龄段中，皮质骨的百分比从69％下降至65％（p <0.0001）。老年男性的轴皮质BMD降低4％（p <0.0001）。结论：美国老年男性的股骨形态和vBMD差异很大。指示股骨颈建模和重塑的模式与杆身中的模式不同。值得注意的是，构成皮质变薄的骨膜和骨内膜尺寸变化在颈部和杆身看来有所不同。

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