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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study.
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Incidence and risk factors for vertebral fracture in women and men: 25-year follow-up results from the population-based Framingham study.

机译：男女椎骨骨折的发病率和危险因素：基于人群的Framingham研究的25年随访结果。

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This study evaluates baseline characteristics of 704 women and men in the Framingham Study with respect to long-term risk of incident vertebral fracture. Incidence was 24% in women and 10% in men. Few factors in middle-aged persons, except prevalent (moderate) fracture and alcohol consumption (in men), predicted long-term incidence of vertebral fracture. INTRODUCTION: We studied potential risk factors in women and men in middle adult years to help identify individuals at increased long-term risk of vertebral fracture in advanced age. MATERIALS AND METHODS: Participants included Framingham cohort members who underwent radiographic examinations at baseline in 1967-1969 (mean age, 53 years) and follow-up in 1992-1993. Semiquantitative methods were used to determine incident fracture, defined as any vertebral body graded normal at baseline and at least mildly deformed (20-25% reduction or more in any vertebral height) at follow-up. Information on potential risk factors was obtained from examinations conducted at or before baseline radiography. RESULTS: Prevalence of vertebral fracture was similar (14%) in women and men, although incidence was greater in women (24%) than men (10%). Alcohol consumption increased fracture risk in men. Multivariable-adjusted ORs increased from 1.78 in men who consumed 1-3 oz of alcohol per week in middle-age years to 4.61 in those with intakes of > or =4 oz/week (trend, P = 0.0099). Age, height, weight, grip strength, physical activity, metacarpal cortical area, and estrogen use (in women) had little or no influence on cumulative incidence of vertebral fracture. Results were similar when fracture was restricted to (at least) moderate severity; however, participants with moderate to severe fracture prevalent at baseline had five times the incidence of moderate to severe fracture during follow-up compared with those without moderately to severe prevalent fractures. CONCLUSIONS: Few factors in middle-aged persons, except prevalent fracture and alcohol consumption (in men), predict long-term incidence of vertebral fracture. The explanation underlying this finding is not readily apparent, however, risk factors for vertebral fracture may be more relevant to older individuals, with respect to short-term fracture risk, than to middle-aged adults in relation to long-term risk with aging.
机译：这项研究评估了Framingham研究中704位男女的基线特征，这些特征涉及椎骨骨折的长期风险。女性的发病率为24％，男性为10％。除了普遍的（中度）骨折和饮酒（男性）以外，中年人很少有因素预测椎骨骨折的长期发生。简介：我们研究了成年后男性和女性的潜在危险因素，以帮助确定在高龄时椎骨骨折长期风险增加的个体。材料与方法：参与者包括Framingham队列成员，他们于1967-1969年接受了射线照相检查（平均年龄53岁），并于1992-1993年进行了随访。使用半定量方法来确定事件性骨折，定义为基线时分级为正常的任何椎体，并在随访时至少发生轻度变形（任何椎体高度减少20-25％或更多）。有关潜在危险因素的信息是从在基线X射线照相术之前或之前进行的检查获得的。结果：女性和男性的椎骨骨折患病率相似（14％），尽管女性（24％）的发病率高于男性（10％）。饮酒会增加男性的骨折风险。多变量调整后的OR值从中年每周饮酒1-3盎司的男性的1.78增加到摄入量≥4盎司/周的男性的4.61（趋势，P = 0.0099）。年龄，身高，体重，握力，身体活动，掌骨皮质区域和雌激素的使用（在女性中）对椎骨骨折的累积发生率几乎没有影响。当骨折仅限于（至少）中等严重程度时，结果相似。然而，基线时普遍存在中度至重度骨折的参与者，其随访期间中度至重度骨折的发生率是没有中度至重度普遍性骨折的参与者的五倍。结论：除了普遍的骨折和饮酒（男性）以外，很少有中年人能预测椎骨骨折的长期发生率。关于这一发现的解释尚不十分清楚，但是，就短期骨折风险而言，就老年人的长期风险而言，与短期骨折风险相比，对于老年人而言，椎骨骨折的风险因素可能更为相关。

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