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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Seasonal change in osteoid thickness and mineralization lag time in ambulant patients.
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Seasonal change in osteoid thickness and mineralization lag time in ambulant patients.

机译：流动患者类固醇厚度和矿化滞后时间的季节性变化。

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Low vitamin D levels are common. Bone biopsies taken from 121 ambulant patients were therefore reviewed. Seasonal changes in mineralization correlated inversely with serum 25-hydroxyvitamin D but not the more active metabolite, 1,25-dihydroxyvitamin D. This implies that the latter is produced in bone. INTRODUCTION: It has been 30 yr since a seasonal variation in osteoid surfaces and calcification fronts was noted in bone biopsies from hip fracture patients in Leeds and attributed to vitamin D status. It was suggested at that time that mild vitamin D deficiency might cause osteoporosis from malabsorption of calcium and more severe deficiency osteomalacia, but little has been published on this subject since. MATERIALS AND METHODS: We examined bone biopsies, calcium absorption data, and serum vitamin D metabolites in 121 patients attending our osteoporosis clinics in Adelaide. Biopsies were collected from the anterior iliac crest with a Jamshidi needle after two stat oral doses of 1 g of tetracycline 10 days apart, processed into plastic without demineralization, and all parameters were measured by point counting using a Weibel II graticule. Calcium absorption was measured after an oral dose of 5 microCi of (45)Ca in 250 ml of water with 20 mg of calcium carrier. Serum 25-hydroxyvitamin D [25(OH)D] was measured by radioimmunoassay and 1,25-dihydroxyvitamin D [1,25(OH)(2)D] by radioimmunoassay after high-performance liquid chromatography (HPLC). RESULTS: 25(OH)D levels were lower from late autumn to early spring (April to September) than from late spring to early autumn (October to March) (51 +/- 23 versus 61 +/- 27 [SD] nM; p=0.040). None of the biopsies yielded a diagnosis of osteomalacia, but osteoid thickness (O.Th.) was greater in the winter than the summer months (8.5 +/- 3.6 versus 7.1 +/- 2.8 microm; p=0.015) as was mineralization lag time (MLT; 11.9 +/- 5.2 versus 9.5 +/- 3.6; p=0.005). O.Th and log MLT were both inversely related to serum 25(OH)D (p=0.014 and 0.036) but not serum 1,25(OH)(2)D. Calcium absorption was related to serum 1,25(OH)(2)D but not serum 25(OH)D. CONCLUSIONS: We conclude that circulating 25(OH)D affects the mineralization process, whereas circulating 1,25(OH)(2)D affects bone indirectly through its effect on calcium absorption.
机译：低维生素D水平很常见。因此，对从121名出诊的患者身上进行的骨活检进行了回顾。矿化的季节性变化与血清25-羟基维生素D呈负相关，而与活性较高的代谢物1,25-二羟基维生素D则不相关。这表明后者在骨骼中产生。简介：距利兹地区髋部骨折患者的骨活检标本中类固醇表面和钙化前沿存在季节性变化，并归因于维生素D状态，距今已有30年了。当时有人提出，轻度维生素D缺乏症可能是由于钙吸收不良而引起的骨质疏松症，更严重的是缺乏骨软化症，但此后几乎没有发表过。材料与方法：我们检查了阿德莱德骨质疏松诊所的121例患者的骨活检，钙吸收数据和血清维生素D代谢产物。两次静注口服剂量1 g四环素，间隔10天后，用Jamshidi针从前terior采集活检样品，将其加工成无矿物质的塑料，并使用Weibel II刻度通过点计数来测量所有参数。在含20 mg钙载体的250 ml水中口服5 microCi（45）Ca后，测量钙吸收。高效液相色谱（HPLC）后，通过放射免疫分析测定血清25-羟基维生素D [25（OH）D]，通过放射免疫分析测定1,25-二羟基维生素D [1,25（OH）（2）D]。结果：从秋末到初春（4月至9月）的25（OH）D水平低于春末至初秋（10月至3月）（51 +/- 23 vs 61 +/- 27 [SD] nM; p = 0.040）。没有活组织检查可诊断出骨软化症，但冬天的类骨质厚度（O.Th.）大于夏季月份（8.5 +/- 3.6对7.1 +/- 2.8微米; p = 0.015），因为矿化滞后时间（MLT; 11.9 +/- 5.2与9.5 +/- 3.6; p = 0.005）。 O.Th和log MLT均与血清25（OH）D呈负相关（p = 0.014和0.036），但与血清1,25（OH）（2）D不相关。钙吸收与血清1,25（OH）（2）D相关，但与血清25（OH）D不相关。结论：我们得出结论，循环25（OH）D影响矿化过程，而循环1,25（OH）（2）D通过其对钙吸收的影响间接影响骨骼。

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