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The Road to Reproducibility in Animal Research

机译:动物研究中的可重复性之路

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摘要

Reproducibility of research findings is the hallmark of scientific advance. However, the recently noted lack of reproducibility and transparency of published research using animal models of human biology and disease has alarmed funders, scientists, and the public. Improved reporting of methodology and better use of statistical tools are needed to enhance the quality and utility of published research. Reporting guidelines like Animal Research: Reporting In Vivo Experiments (ARRIVE) have been devised to achieve these goals, but most biomedical research journals, including the JBMR, have not been able to obtain high compliance. Cooperative efforts among authors, reviewers and editors-empowered by increased awareness of their responsibilities, and enabled by user-friendly guidelines-are needed to solve this problem. (C) 2016 American Society for Bone and Mineral Research.
机译:研究结果的可重复性是科学进步的标志。但是,最近指出的使用人类生物学和疾病的动物模型发表的研究缺乏可重复性和透明度,这令资助者,科学家和公众感到震惊。需要改进方法的报告并更好地利用统计工具,以提高已发表研究的质量和效用。已经设计出了诸如动物研究:体内实验报告(ARRIVE)之类的报告指南来实现这些目标,但是大多数生物医学研究期刊,包括JBMR,都未能获得很高的依从性。解决此问题需要作者,审阅者和编辑之间的合作努力,这是由于人们对其职责的认识日益增强,并且受到用户友好的指南的支持。 (C)2016美国骨矿物质研究学会。

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