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首页> 外文期刊>Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research >Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism
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Concurrent Hypoparathyroidism Is Associated With Impaired Physical Function and Quality of Life in Hypothyroidism

机译：并发性甲状旁腺功能减退症与甲状腺功能减退症的身体功能和生活质量受损有关

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摘要

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, as a complication patients may also develop hypoparathyroidism (HypoPT). The aim of this study was to assess quality of life (QoL), muscle function, and postural stability in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls. Age- and gender-matched patients on treatment for HypoT+PT and HypoT were recruited from our outpatient clinic. Matched healthy controls were recruited from the general background population. Compared with controls, HypoT was associated with a significantly lower mental summary score, whereas patients with HypoT+PT had a significantly lower physical summary score (Short Form 36 Health Survey questionnaire version 2). Moreover, the physical component score was significantly lower in patients with HypoT+PT compared with HypoT. WHO-5 well-being index was significantly lower in both groups of patients compared with controls, but did not differ between groups of patients. Compared with controls, muscle strength and maximal force production was significantly reduced in HypoT+PT, but not in HypoT. In HypoT+PT, the time spent on the Timed Up & Go test and the Repeated Chair Stands test were significantly longer than in the HypoT group and the control group. Postsurgical HypoT+PT is associated with a more severe impairment of QoL, in particular regarding physical functioning, than HypoT. HypoT+PT patients are also hampered by impaired muscle function. Studies on how to improve well-being and muscle function in HypoT+PT patients are warranted. (C) 2016 American Society for Bone and Mineral Research.
机译：全甲状腺切除术会导致术后甲状腺功能减退（HypoT）。除HypoT外，作为一种并发症，患者还可能发展为甲状旁腺功能低下（HypoPT）。这项研究的目的是评估术后甲减和甲状旁腺功能低下（HypoT + PT）患者的生活质量（QoL），肌肉功能和姿势稳定性。从我们的门诊招募了年龄和性别相匹配的接受HypoT + PT和HypoT治疗的患者。从一般背景人群中招募相匹配的健康对照。与对照组相比，HypoT的心理摘要得分显着降低，而HypoT + PT的患者的生理摘要得分显着更低（简短的36型健康调查问卷第2版）。此外，与HypoT相比，HypoT + PT患者的身体成分评分明显更低。与对照组相比，两组患者的WHO-5健康指数均显着降低，但两组患者之间没有差异。与对照组相比，HypoT + PT的肌肉力量和最大力量产生显着降低，但HypoT没有。在HypoT + PT中，Timed Up＆Go测试和重复椅座测试所花费的时间明显长于HypoT组和对照组。与HypoT相比，术后HypoT + PT与QoL的更严重损害有关，特别是在身体功能方面。 HypoT + PT患者也受到肌肉功能受损的困扰。有必要研究如何改善HypoT + PT患者的健康状况和肌肉功能。 （C）2016美国骨矿物质研究学会。

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