Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase.

Bello CG; Harris JM; Manthey MK; Coggins JR; Abell C

首页> 外文期刊>Bioorganic and Medicinal Chemistry Letters >Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase.

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Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase.

机译：II型脱氢奎宁酶的底物对I型脱氢奎宁酶的不可逆抑制作用。

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Mechanistic differences between type I and type II dehydroquinases have been exploited in the design of type specific inhibitors. (2R)-2-Bromo-3-dehydroquinic acid (3), (2R)-2-fluoro-3-dehydroquinic acid (5) and 2-bromo-3-dehydroshikimic acid (4), all excellent substrates for type II dehydroquinase, are shown to be irreversible inhibitors of type I dehydroquinase.

机译：在类型特异性抑制剂的设计中已经利用了I型和II型脱氢喹啉酶之间的机理差异。（2R）-2-溴-3-脱氢奎尼酸（3），（2R）-2-氟-3-脱氢奎尼酸（5）和2-溴-3-脱氢shi草酸（4），都是II型优异的底物脱氢奎宁酶被证明是I型脱氢奎宁酶的不可逆抑制剂。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2000年第5期|共3页
作者
Bello CG; Harris JM; Manthey MK; Coggins JR; Abell C;
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正文语种 eng
中图分类药学;生物化学;
关键词
Enzyme Inhibitors; Hydro-Lyases; Quinic Acid; Shikimic Acid; 3-dehydroquinate dehydratase; 酶抑制剂; 氢裂合酶类; 奎尼酸; 莽草酸;

机译：Enzyme Inhibitors;Hydro-Lyases;Quinic Acid;Shikimic Acid;3-dehydroquinate dehydratase;酶抑制剂;氢裂合酶类;奎尼酸;莽草酸;

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2. Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase. [J] . Bello CG, Harris JM, Manthey MK, Bioorganic and Medicinal Chemistry Letters . 2000,第5期

机译：II型脱氢奎宁酶的底物对I型脱氢奎宁酶的不可逆抑制作用。
3. Inhibitors of types I and II dehydroquinase. [J] . Le Sann C, Gower MA, Abell AD Mini reviews in medicinal chemistry . 2004,第7期

机译：I和II型脱氢喹啉酶的抑制剂。
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8. Synthesis and biological evaluation of new nanomolar competitive inhibitors of Helicobacter pylori type II dehydroquinase. Structural details of the role of the aromatic moieties with essential residues [O] . Prazeres Verónica F. V., Raaij Mark J. van, González-Bello Concepción 2013

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Irreversible inhibition of type I dehydroquinase by substrates for type II dehydroquinase.

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