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首页> 外文期刊>Journal of breath research >Increased concentrations of breath haloamines are not detectable in airways inflammation using SIFT-MS
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Increased concentrations of breath haloamines are not detectable in airways inflammation using SIFT-MS

机译：使用SIFT-MS在气道炎症中无法检测到呼吸中卤代胺的浓度增加

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摘要

The haloamines, including the chloramines (H_2NCl, HNCl _2) and bromamine (H_2NBr), are diffusible gases that are likely to be produced during inflammation and so may be present as markers of lung inflammation on breath. Although haloamines are quite reactive, it is possible to measure these compounds in humid samples using SIFT-MS. Until recently the quantification of haloamines in breath suffered from interference from other common breath compounds. This was overcome by heating the flow tube which removed major water cluster product ions. Despite the improvements to the method, previous attempts to measure the haloamines in breath samples from normal volunteers had found no evidence to support their presence. Since it is proposed that the haloamines may be present in higher concentrations during airways inflammation we have attempted to detect the compounds in the exhaled breath of patients with airways inflammatory conditions. On-line and off-line breath samples were analyzed; however, there was no discernable change to any of product ions when compared to ambient air or normal subjects. This suggests that despite sensitivity in the mid part per trillion range haloamines are not significantly raised in airways inflammation.
机译：卤胺，包括氯胺（H_2NCl，HNCl _2）和溴胺（H_2NBr），是在炎症过程中可能产生的可扩散气体，因此可能作为呼吸道肺部炎症的标志物而存在。尽管卤胺具有很强的反应性，但可以使用SIFT-MS测定潮湿样品中的这些化合物。直到最近，呼吸中卤代胺的定量还受到其他常见呼吸化合物的干扰。通过加热除去主要水簇产物离子的流量管可以克服这一问题。尽管该方法有所改进，但以前尝试测量正常志愿者呼吸样本中的卤代胺的尝试均未发现任何证据支持其存在。由于建议在气道炎症期间卤代胺可能以更高的浓度存在，因此我们尝试在患有气道炎症状况的患者呼出气中检测化合物。分析了在线和离线呼吸样本;但是，与环境空气或正常对象相比，任何产物离子都没有明显变化。这表明，尽管敏感性在每万亿范围的中间，卤代胺在气道炎症中并未显着升高。

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