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首页> 外文期刊>Journal of breath research >Physiological variability in volatile organic compounds (VOCs) in exhaled breath and released from faeces due to nutrition and somatic growth in a standardized caprine animal model
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Physiological variability in volatile organic compounds (VOCs) in exhaled breath and released from faeces due to nutrition and somatic growth in a standardized caprine animal model

机译：在标准的山羊动物模型中，由于营养和体细胞生长，呼气中挥发性有机化合物（VOC）的生理变异性从粪便中释放出来

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摘要

Physiological effects may change volatile organic compound (VOC) concentrations and may therefore act as confounding factors in the definition of VOCs as disease biomarkers. To evaluate the extent of physiological background variability, this study assessed the effects of feed composition and somatic growth on VOC patterns in a standardized large animal model. Fifteen clinically healthy goats were followed during their first year of life. VOCs present in the headspace over faeces, exhaled breath and ambient air inside the stable were repeatedly assessed in parallel with the concentrations of glucose, protein, and albumin in venous blood. VOCs were collected and analysed using solid-phase or needle-trap microextraction and gas chromatograpy together with mass spectroscopy. The concentrations of VOCs in exhaled breath and above faeces varied significantly with increasing age of the animals. The largest variations in volatiles detected in the headspace over faeces occurred with the change from milk feeding to plant-based diet. VOCs above faeces and in exhaled breath correlated significantly with blood components. Among VOCs exhaled, the strongest correlations were found between exhaled nonanal concentrations and blood concentrations of glucose and albumin. Results stress the importance of a profound knowledge of the physiological backgrounds of VOC composition before defining reliable and accurate marker sets for diagnostic purposes.
机译：生理效应可能会改变挥发性有机化合物（VOC）的浓度，因此可能在将VOC定义为疾病生物标记时充当混淆因素。为了评估生理背景变化的程度，本研究评估了饲料组成和体细胞生长对标准化大型动物模型中VOC模式的影响。在其生命的第一年中，对十五只临床健康的山羊进行了跟踪。反复评估粪便顶部空间，呼出气和周围空气中的挥发性有机化合物与静脉血中葡萄糖，蛋白质和白蛋白的浓度。收集VOC，并使用固相或针阱微萃取，气相色谱和质谱联用进行分析。呼气和粪便中挥发性有机化合物的浓度随动物年龄的增长而显着变化。从粪便喂养到以植物为基础的饮食变化，在粪便的顶部空间中检测到的挥发物变化最大。粪便上方和呼气中的挥发性有机化合物与血液成分显着相关。在呼出的挥发性有机化合物中，发现呼出的非肛门浓度与血液中葡萄糖和白蛋白浓度之间的相关性最强。结果强调了为诊断目的定义可靠和准确的标记物组之前，对VOC组成的生理背景有深刻了解的重要性。

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