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首页> 外文期刊>Journal of breath research >Hydrogen sulphide in exhaled breath: a potential biomarker for small intestinal bacterial overgrowth in IBS
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Hydrogen sulphide in exhaled breath: a potential biomarker for small intestinal bacterial overgrowth in IBS

机译：呼出气中的硫化氢：IBS中小肠细菌过度生长的潜在生物标志物

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摘要

There is a pressing need to develop a novel early-detection strategy for the precise evolution of small intestinal bacterial overgrowth (SIBO) in irritable bowel syndrome (IBS) patients. The current method based on a hydrogen breath test (HBT) for the detection of SIBO is highly controversial. HBT has many limitations and drawbacks. It often fails to indentify SIBO when IBS individuals have 'non-hydrogen-producing' colonic bacteria. Here, we show that hydrogen sulphide (H2S) in exhaled breath is distinctly altered for diarrhea-predominant IBS individuals with positive and negative SIBO by the activity of intestinal sulphate-reducing bacteria. Subsequently, by analyzing the excretion kinetics of breath H2S, we found a missing link between breath H2S and SIBO when HBT often fails to diagnose SIBO. Moreover, breath H2S can track the precise evolution of SIBO, even after the eradication of bacterial overgrowth. Our findings suggest that the changes in H2S in the bacterial environment may contribute to the pathogenesis of SIBO and the breath H2S as a potential biomarker for non-invasive, rapid and precise assessment of SIBO without the endoscopy-based microbial culture of jejunal aspirates, and thus may open new perspectives into the pathophysiology of SIBO in IBS subjects.
机译：迫切需要开发一种新颖的早期检测策略，以在肠易激综合征（IBS）患者中精确发展小肠细菌过度生长（SIBO）。目前基于氢呼气试验（HBT）的SIBO检测方法备受争议。 HBT具有许多局限性和缺点。当IBS个体患有“不产氢”的结肠细菌时，通常无法识别SIBO。在这里，我们显示，通过减少肠道内硫酸盐细菌的活性，呼出气中的硫化氢（H2S）对于SIBO阳性和阴性的腹泻型IBS个体具有明显的改变。随后，通过分析呼吸H2S的排泄动力学，我们发现，当HBT经常无法诊断SIBO时，呼吸H2S与SIBO之间缺少联系。而且，即使在消除细菌过度生长之后，呼吸H2S仍可追踪SIBO的精确演变。我们的发现表明，细菌环境中H2S的变化可能有助于SIBO的发病机理和呼吸H2S，这是无创，快速，准确评估SIBO的潜在生物标志物，而无需基于内窥镜的空肠抽吸物微生物培养，并且因此可以为IBS受试者的SIBO的病理生理学开辟新的视野。

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