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首页> 外文期刊>Journal of Alzheimer's disease: JAD >Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1.
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Neuronal cytoskeletal dynamic modification and neurodegeneration induced by infection with herpes simplex virus type 1.

机译：1型单纯疱疹病毒感染引起的神经元细胞骨架动态修饰和神经变性。

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摘要

Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) belong to the family Herpesviridae, the subfamily Alphaherpesvirinae, and the genus Simplexvirus. They are ubiquitous, neurotropic, and the most common pathogenic cause of sporadic acute encephalitis in humans. Herpes simplex encephalitis (HSE) is associated with a high mortality rate and significant neurological, neuropsychological, and neurobehavioral sequelae, which afflict patients for life. HSV-1 has been suggested as an environmental risk factor for Alzheimer's disease. However, the mechanisms involved in HSV-1 infection that may trigger the neurodegenerative process are still unknown. In general, HSV-1 induced cytoskeletal alterations reported to date involve the overall disruption of one or more elements of the cytoskeleton in cell lines. Axonal injury has recently attracted attention as a key predictor for the outcome of a number of brain disorders. Here we show that infection of mice neuronal cultures with HSV-1 result in marked neurite damage and neuronal death. Furthermore, in this in vitro model of infection, neurons manifested considerable alterations in microtubule dynamics and tau hyperphosphorylation. These results suggest a possible link between HSV-1 infection and neuronal cytoskeletal disruption.
机译：单纯疱疹病毒1型（HSV-1）和单纯疱疹病毒2型（HSV-2）属于疱疹病毒科，Alphaherpesvirinae亚科和单纯疱疹病毒属。它们是普遍存在的神经质性疾病，是人类散发性急性脑炎的最常见病因。单纯疱疹性脑炎（HSE）与高死亡率和严重的神经，神经心理和神经行为后遗症相关，这些疾病困扰着患者一生。 HSV-1被认为是阿尔茨海默氏病的环境危险因素。但是，HSV-1感染可能触发神经变性过程的机制仍是未知的。通常，迄今为止报道的HSV-1诱导的细胞骨架改变涉及细胞系中细胞骨架的一种或多种元素的整体破坏。轴突损伤最近已引起关注，因为它是许多脑部疾病的预后指标。在这里，我们表明，用HSV-1感染小鼠神经元培养物会导致明显的神经突损伤和神经元死亡。此外，在这种体外感染模型中，神经元表现出微管动力学和tau过度磷酸化的显着变化。这些结果表明HSV-1感染和神经元细胞骨架破坏之间的可能联系。

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