The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.

Souto ML; Manriquez CP; Norte M; Leira F; Fernandez JJ

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The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.

机译：角鲨烯衍生的三萜对蛋白磷酸酶PP2A的抑制作用。

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This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.

机译：本文报道了测试15种带有角鲨烯碳骨架的聚醚三萜对2A型蛋白磷酸酶的抑制作用。两种化合物16-羟基脱氢甲状腺甾醇10和thyrsenol B 14在浓度为10 microM时显示出显着的抑制作用。与thyrsiferyl-23-acetate 1的比较表明，C-15或C-16周围羟基的类似空间布置是这些代谢物共有的结构特征。

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来源
《Bioorganic and Medicinal Chemistry Letters》 |2003年第7期|共4页
作者
Souto ML; Manriquez CP; Norte M; Leira F; Fernandez JJ;
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正文语种 eng
中图分类基础医学;
关键词
Enzyme Inhibitors; Phosphoprotein Phosphatase; Squalene; Triterpenes; 酶抑制剂; 磷蛋白磷酸酶; 角鲨烯; 三萜类;

机译：Enzyme Inhibitors;Phosphoprotein Phosphatase;Squalene;Triterpenes;酶抑制剂;磷蛋白磷酸酶;角鲨烯;三萜类;

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1. The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A. [J] . Souto ML, Manriquez CP, Norte M, Bioorganic and Medicinal Chemistry Letters . 2003,第7期

机译：角鲨烯衍生的三萜对蛋白磷酸酶PP2A的抑制作用。
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The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.

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