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首页> 外文期刊>Journal of Alzheimer's disease: JAD >Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis
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Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer's Disease: A Meta-Analysis

机译：胆固醇，24-羟基胆固醇和27-羟基胆固醇作为轻度认知障碍和阿尔茨海默氏病脑脊液中替代生物标志物的Meta分析

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摘要

Abnormal cholesterol metabolism is an established feature of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) is the fluid surrounding the central nervous system, and the protein and lipid content alterations in the CSF could be biomarkers for degenerative changes in the brain. The laboratory diagnosis of AD is limited to the analysis of three biomarkers in CSF: A beta(42), total tau, and phospho-tau. The purpose of this analysis is to systematically analyze the available data describing the biomarkers of cholesterol and its metabolites in the CSF of subjects with AD. MEDLINE, EMBASE, and the Cochrane Central database were systematically queried to collect studies that have evaluated the markers of cholesterol and its metabolites in the CSF of subjects with mild cognitive impairment (MCI) or AD and age-matched controls. Analysis of the published data shows that the levels of cholesterol are increased in MCI subjects; 24-hydroxycholesterol and 27-hydroxycholesterol are elevated in AD and MCI subjects compared to controls. There is a significant dysfunction of cholesterol metabolism in the CSF of AD subjects. This analysis indicates that in addition to the available biomarkers in the CSF, such as A beta(42), total tau, and phospho-tau, 24-hydroxycholesterol, 27-hydroxycholesterol, and cholesterol appear to be sensitive biomarkers for the evaluation of MCI and AD.
机译：胆固醇代谢异常是阿尔茨海默氏病（AD）的既定特征。脑脊液（CSF）是中枢神经系统周围的液体，CSF中蛋白质和脂质含量的变化可能是大脑退行性变化的生物标记。 AD的实验室诊断仅限于分析CSF中的三种生物标记：Aβ（42），总tau和磷酸化tau。该分析的目的是系统地分析描述AD患者CSF中胆固醇及其代谢物生物标志物的可用数据。系统地查询MEDLINE，EMBASE和Cochrane Central数据库，以收集评估患有轻度认知障碍（MCI）或AD以及年龄匹配的对照组的CSF中胆固醇及其代谢物标志物的研究。对已发表数据的分析表明，MCI受试者的胆固醇水平升高;与对照组相比，AD和MCI受试者中的24-羟基胆固醇和27-羟基胆固醇升高。在AD受试者的CSF中存在胆固醇代谢的显着功能障碍。该分析表明，除了脑脊液中可用的生物标志物，例如A beta（42），总tau和磷酸化tau外，24-羟基胆固醇，27-羟基胆固醇和胆固醇似乎是评估MCI的敏感生物标志物和广告。

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