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首页> 外文期刊>Journal of cardiac failure >Depressive symptom trajectory predicts 1-year health-related quality of life in patients with heart failure.
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Depressive symptom trajectory predicts 1-year health-related quality of life in patients with heart failure.

机译：抑郁症状轨迹可预测心衰患者1年健康相关的生活质量。

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BACKGROUND: One-third of patients with heart failure (HF) experience depressive symptoms that adversely affect health-related quality of life (HRQOL). We aimed to describe depressive symptom trajectory and determine whether a change in depressive symptoms predicts subsequent HRQOL. METHODS AND RESULTS: The sample consisted of 256 inpatients and outpatients with HF. Depressive symptoms were measured at baseline and 3 or 6 months with the Patient Health Questionnaire (PHQ-9). The Minnesota Living with HF Questionnaire was used to assess HRQOL at baseline, 3 to 6 months, and 1 year. Based on baseline and 3- to 6-month PHQ-9 scores, patients were categorized as depressive symptom-free (64%), depressive symptoms improved (15%), depressive symptoms developed (6%), or persistent depressive symptoms (15%). The groups differed in 1-year HRQOL levels (F = 36, P < .001); patients who were depressive symptom-free or whose depressive symptoms improved had better 1-year HRQOL than patients with persistent depressive symptoms (Tukey honestly significant difference, P < .01). Change in depressive symptoms was the strongest predictor of 1-year HRQOL (standardized beta = .42, P < .001), after controlling for functional status, demographics, and clinical variables. CONCLUSIONS: We found the trajectory of depressive symptoms predicts future HRQOL. Research is needed to determine whether interventions targeting depressive symptoms improve HRQOL in patients with HF.
机译：背景：三分之一的心力衰竭（HF）患者会出现抑郁症状，对健康相关的生活质量（HRQOL）产生不利影响。我们旨在描述抑郁症状的轨迹，并确定抑郁症状的改变是否预示了随后的HRQOL。方法和结果：样本由256名住院和门诊HF患者组成。用患者健康问卷（PHQ-9）在基线和3或6个月时测量抑郁症状。使用明尼苏达州HF问卷调查在基线，3至6个月和1年时评估HRQOL。根据基线和3个月至6个月的PHQ-9评分，将患者分为无抑郁症状（64％），抑郁症状改善（15％），抑郁症状发展（6％）或持续抑郁症状（15） ％）。两组的一年HRQOL水平有所不同（F = 36，P <.001）;无抑郁症状或抑郁症状得到改善的患者，其1年HRQOL优于持续抑郁症状的患者（Tukey的差异有统计学意义，P <.01）。在控制功能状态，人口统计学和临床​​变量后，抑郁症状的变化是1年HRQOL的最强预测指标（标准β= 0.42，P <.001）。结论：我们发现抑郁症状的轨迹预测未来的HRQOL。需要进行研究以确定针对抑郁症状的干预措施是否可以改善HF患者的HRQOL。

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