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首页> 外文期刊>Journal of cardiac failure >A positive 2-item patient health questionnaire depression screen among hospitalized heart failure patients is associated with elevated 12-month mortality
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A positive 2-item patient health questionnaire depression screen among hospitalized heart failure patients is associated with elevated 12-month mortality

机译：住院心力衰竭患者中2项患者健康问卷抑郁筛查结果呈阳性与12个月死亡率上升相关

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摘要

Background: Given the association of depression with poorer cardiac outcomes, an American Heart Association Science Advisory has advocated routine screening of cardiac patients for depression using the 2-item Patient Health Questionnaire (PHQ-2) "at a minimum." However, the prognostic value of the PHQ-2 among HF patients is unknown. Methods and Results: We screened hospitalized HF patients (ejection fraction [EF] <40%) that staff suspected may be depressed with the PHQ-2, and then determined vital status at up to 12-months follow-up. At baseline, PHQ-2 depression screen-positive patients (PHQ-2+; n = 371), compared with PHQ-2 screen-negative patients (PHQ-2-; n = 100), were younger (65 vs 70 years) and more likely to report New York Heart Association (NYHA) functional class III/IV than class II symptoms (67% vs. 39%) and lower levels of physical and mental health-related quality of life (all P ≤.002); they were similar in other characteristics (65% male, 26% mean EF). At 12 months, 20% of PHQ-2+ versus 8% of PHQ-2- patients had died (P =.007) and PHQ-2 status remained associated with both all-cause (hazard ratio [HR] 3.1, 95% confidence interval [CI] 1.4-6.7; P =.003) and cardiovascular (HR 2.7, 95% CI 1.1-6.6; P =.03) mortality even after adjustment for age, gender, EF, NYHA functional class, and a variety of other covariates. Conclusions: Among hospitalized HF patients, a positive PHQ-2 depression screen is associated with an elevated 12-month mortality risk.
机译：背景：考虑到抑郁与心脏预后不良之间的关联，美国心脏协会科学咨询委员会提倡“至少使用2项患者健康调查表（PH​​Q-2）”对心脏病患者进行常规筛查。但是，PHQ-2在HF患者中的预后价值尚不清楚。方法和结果：我们筛查了住院的HF患者（射血分数[EF] <40％），怀疑其工作人员可能被PHQ-2压抑，然后在长达12个月的随访中确定了生命状态。基线时，PHQ-2抑郁筛查阳性患者（PHQ-2 +; n = 371）比PHQ-2筛查阴性患者（PHQ-2-; n = 100）年轻（65岁与70岁）报告纽约心脏协会（NYHA）功能性III / IV级而不是II级症状的可能性更高（分别为67％和39％）以及与身心健康相关的生活质量较低的水平（所有P≤.002）;他们在其他特征上相似（男性65％，平均EF为26％）。在12个月时，PHQ-2 +患者的20％与PHQ-2患者的8％死亡（P = .007），并且PHQ-2的状态仍然与两种原因相关（危险比[HR] 3.1，95％置信区间[CI]为1.4-6.7; P = .003）和心血管（HR 2.7，95％CI 1.1-6.6; P = .03）死亡率，即使在调整了年龄，性别，EF，NYHA功能等级和各种因素后其他协变量结论：在住院的HF患者中，PHQ-2抑郁筛查阳性与12个月死亡风险升高相关。

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