Cage amines as the stopper inhibitors of cholinesterases.

Lin G; Tsai HJ; Tsai YH

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Cage amines as the stopper inhibitors of cholinesterases.

机译：笼型胺作为胆碱酯酶的终止剂。

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Cage amines 1-4 are potent peripheral anionic site-bound reversible inhibitors of both acetylcholinesterase and butyrylcholinesterase. Cage amines 1-3 are selective butyrylcholinesterase inhibitor versus acetylcholinesterase. For both enzymes, the -log K(i) values linearly correlate with the difference of substituted phenyl radius of cage amines (-log K(i)=5.4+3.4Deltagamma for acetylcholinesterase, -log K(i)=5.9+3.2Deltagamma for butyrylcholinesterase). Moreover, the relationship between the enzymes and cage amines mimics that between bottles and stoppers.

机译：笼型胺1-4是乙酰胆碱酯酶和丁酰胆碱酯酶的有效的外围阴离子位点结合的可逆抑制剂。笼胺1-3是选择性丁酰胆碱酯酶抑制剂，而不是乙酰胆碱酯酶。对于这两种酶，-log K（i）值均与笼型胺的取代苯基半径之差线性相关（对于乙酰胆碱酯酶，-log K（i）= 5.4 + 3.4Deltagamma，-log K（i）= 5.9 + 3.2Deltagamma用于丁酰胆碱酯酶）。此外，酶和笼型胺之间的关系类似于瓶子和塞子之间的关系。

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《Bioorganic and Medicinal Chemistry Letters》 |2003年第17期|共4页
作者
Lin G; Tsai HJ; Tsai YH;
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正文语种 eng
中图分类基础医学;
关键词
Amines; Spinal cage; inhibitors; Acetylcholinesterase; 胺类; 乙酰胆碱酯酶;

机译：Amines;Spinal cage;inhibitors;Acetylcholinesterase;胺类;乙酰胆碱酯酶;

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1. Cage amines as the stopper inhibitors of cholinesterases. [J] . Lin G, Tsai HJ, Tsai YH Bioorganic and Medicinal Chemistry Letters . 2003,第17期

机译：笼型胺作为胆碱酯酶的终止剂。
2. Kinetics and structure-activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases. [J] . Atta ur Rahman, Choudhary MI Bioorganic and medicinal chemistry . 2004,第9期

机译：动力学和构效关系的研究对抑制胆碱酯酶的孕烷型甾体生物碱。
3. Kinetics and structure-activity relationship studies on pregnane-type steroidal alkaloids that inhibit cholinesterases. [J] . Atta ur Rahman, Choudhary MI Bioorganic and Medicinal Chemistry . 2004,第9期

机译：动力学和构效关系的研究对抑制胆碱酯酶的孕烷型甾体生物碱。
4. New poly cyclic cage amines with NMD A receptor antagonist activity [C] . Eva Torres, Marta Lopez-Querol, Francesc X. Sureda European Symposium on Organic Chemistry . 2009

机译：新的聚环笼胺，具有NMD受体拮抗剂活性
5. A PHOTOPHYSICAL STUDY OF THE THERMODYNAMIC AND KINETIC PROPERTIES OF EXCIMER FORMATION IN THE SATURATED CAGE AMINE 1-AZABICYCLO(2.2.2)OCTANE. [D] . STERNFELS, RONALD JULIAN. 1976

机译：在饱和笼型胺1-氮杂双环（2.2.2）己内酰胺中准分子形成的热力学和动力学性质的光物理研究。
6. 7H-pyrrolo23-dpyrimidin-4-amine based inhibitors of calcium dependent protein kinase 1 have distinct inhibitory and oral pharmacokinetic characteristics compared with 1H-pyrazolo34-dpyrimidin-4-amine based inhibitors. [O] . Rama S. R. Vidadala, Martin Golkowski, Matthew A. Hulverson, -1

机译：与1H-吡唑并34-d嘧啶-4-胺基抑制剂相比钙依赖性蛋白激酶1的7H-吡咯并23-d嘧啶-4-胺基抑制剂具有独特的抑制和口服药代动力学特性。
7. The effects of symmetry and rigidity on non-adiabatic dynamics in tertiary amines: a time-resolved photoelectron velocity-map imaging study of the cage-amine ABCO [O] . Klein, Liv B., Morsing, Thorbjørn J., Livingstone, Ruth, 2016

机译：对称性和刚性对叔胺非绝热动力学的影响：笼型胺ABCO的时间分辨光电子速度图成像研究
8. Inhibiting properties and adsorption of an amine based fatty acid corrosion inhibitor on carbon steel in aqueous carbon dioxide solutions [R] . Buchweishaija, J. 1997

机译：在二氧化碳水溶液中抑制胺基脂肪酸腐蚀抑制剂对碳钢的性能和吸附

Cage amines as the stopper inhibitors of cholinesterases.

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