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首页> 外文期刊>Journal of cardiac failure >Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure.
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Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure.

机译：运动训练对慢性心力衰竭的自主神经紊乱和神经体液激活的影响。

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BACKGROUND: In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. METHODS AND RESULTS: After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. CONCLUSIONS: Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.
机译：背景：在慢性心力衰竭（CHF）中，持续的自主神经紊乱和神经体液激活会导致结构性终末器官损害，降低运动能力，并降低生活质量。 CHF的药物治疗和运动训练的有益作用已在各种功能和结构水平上得到了证明。但是，药物治疗尚不能将CHF中的自主神经紊乱和神经体液激活降至最低。各种研究表明，运动训练在这方面是有效的。方法和结果：在审查了可用的证据后，我们得出结论，运动训练可增加压力反射敏感性和心率变异性，并减少交感神经流出，儿茶酚胺，血管紧张素II，血管加压素和静息的脑钠肽的血浆水平。结论：运动训练对CHF具有直接和反射性交感抑制作用。运动训练使自主神经紊乱和神经体液激活正常化的机制，是为了阐明与CHF相关的训练计划的进一步发展，旨在最大程度地提高疗效，同时最大程度地减少工作量。

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