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首页> 外文期刊>Journal of cardiac failure >Relationship between heart failure and lipids: the paradigm continues to evolve.
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Relationship between heart failure and lipids: the paradigm continues to evolve.

机译:心力衰竭与血脂之间的关系:范例不断发展。

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Understanding the relationship between lipids and coronary artery disease has been one of'the most successful stories in cardiovascular medicine. From pathogenesis to risk determination, and from treatment to outcomes, the link between lipids and coronary disease has been intuitively sound and the results consistent across studies. Such is not the case between lipids and heart failure. Several risk factors for adverse outcomes for other cardiovascular diseases such as high blood pressure, high cholesterol levels, and obesity actually are associated with improved outcomes in heart failure. This phenomenon is described as the epidemiologic paradox and is not unique to heart failure, but is seen in other chronic diseases also. However, what is particularly intriguing is that despite these traditional risk factors being paradoxically associated with improved outcomes in heart failure, they are actually associated with a higher risk of development of heart failure in the first place and moreover, in patients with heart failure their treatment may still improve outcomes! Thus truly it is a reverse-reverse epidemiologic paradox and is illustrated in Fig. 1.
机译:了解脂质与冠状动脉疾病之间的关系一直是心血管医学中最成功的故事之一。从发病机制到风险确定,从治疗到结果,脂质和冠状动脉疾病之间的联系一直很直观,并且研究结果一致。脂质与心力衰竭之间并非如此。导致其他心血管疾病不良后果的一些风险因素,例如高血压,高胆固醇和肥胖症,实际上与心力衰竭的改善有关。这种现象被描述为流行病学悖论,并非心力衰竭所独有,但在其他慢性疾病中也可见。然而,特别令人着迷的是,尽管这些传统的危险因素与心力衰竭的改善具有矛盾的关系,但实际上,它们首先与心力衰竭发展的较高风险相关,而且,在心力衰竭患者中,他们的治疗方法可能仍然会改善结果!因此,这确实是一种反向-反向流行病学悖论,如图1所示。

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