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首页> 外文期刊>Journal of cardiac failure >Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure.
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Extracellular matrix turnover and inflammatory markers independently predict functional status and outcome in chronic heart failure.

机译：细胞外基质更新和炎症标志物独立预测慢性心力衰竭的功能状态和结果。

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BACKGROUND: Inflammatory pathways may promote extracellular matrix (ECM) remodeling and chronic heart failure (CHF) progression. The relationship between markers of inflammation and of ECM remodeling, and their influence on functional status and outcomes has not been examined in a large cohort of CHF patients. METHODS AND RESULTS: We measured baseline blood serum collagen (amino-terminal propeptide of collagen III [PIIINP], metalloproteinase 1 [MMP-1], tissue inhibitor of metalloproteinase 1 [TIMP-1]), and inflammatory (high-sensitivity C-reactive protein [(hsCRP], interleukin [IL]-18, IL-10) markers in 1009 patients enrolled in the Research into Etanercept Cytokine Antagonism in Ventricular Dysfunction (RECOVER) trial. A positive correlation was detected between the 2 classes of markers (PIIINP to IL-18, MMP-1 and TIMP-1 to CRP, TIMP-1 to IL-18, MMP-1 to IL-10). In the adjusted multivariable model including all biomarkers, only PIIINP (P = .03) and MMP-1 (P = .048) were independent predictors of 6-minute walk test (6-MWT), whereas in another model including only inflammatory biomarkers, IL-18 was an independent predictor. PIIINP (P = .001) was the only biomarker independently associated with death and CHF hospitalization. CONCLUSIONS: The independent associations of PIIINP and MMP-1 with 6-MWT and PIIINP with CHF morbi-mortality suggest that excessive ECM turnover may be associated with functional capacity deterioration and poor outcome.
机译：背景：炎性途径可能促进细胞外基质（ECM）重塑和慢性心力衰竭（CHF）进展。尚未在大量CHF患者中检查炎症标志物与ECM重塑之间的关系及其对功能状态和结果的影响。方法和结果：我们测量了基线血清胶原蛋白（胶原蛋白III [PIIINP]的氨基末端前肽，金属蛋白酶1 [MMP-1]，金属蛋白酶1的组织抑制剂[TIMP-1]）和炎症性（高敏感性C-参与Etanercept细胞因子拮抗心室功能障碍研究（RECOVER）的1009例患者中的反应性蛋白[（hsCRP]，白介素[IL] -18，IL-10）标记物。两类标记物之间存在正相关性（ PIIINP到IL-18，MMP-1和TIMP-1到CRP，TIMP-1到IL-18，MMP-1到IL-10）在包括所有生物标志物的校正多变量模型中，只有PIIINP（P = .03） MMP-1和MMP-1（P = .048）是6分钟步行测试（6-MWT）的独立预测因子，而在另一个仅包含炎症生物标志物的模型中，IL-18是独立预测因子; PIIINP（P = .001）是结论：PIIINP和MMP-1与6- MWT和PIIINP伴有CHF死亡率，提示ECM转换过多可能与功能能力下降和预后不良有关。

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