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首页> 外文期刊>Journal of cardiac surgery. >Determination of troponin I release after CABG surgery.
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Determination of troponin I release after CABG surgery.

机译：CABG手术后肌钙蛋白I释放的测定。

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BACKGROUND: Troponin I is used to diagnose myocardial infarction (MI). Its use and pattern of elevation is not well defined in coronary artery bypass graft (CABG) surgery. This study assessed the timing of troponin I elevation in patients undergoing urgent CABG. METHOD: Patients undergoing urgent isolated-CABG with cardiopulmonary bypass were studied prospectively. Blood samples were taken to measure CK, CK-MB, and troponin I: preoperatively, 7 hours postoperatively, 14 to 18 hours postoperatively, 30 to 48 hours postoperatively, and on postoperative day 4. Electrocardiograms and in-hospital course were recorded. Perioperative MI (PMI) was defined by either (i) ECG criteria of new Q-waves in the presence of CK-MB elevation >50 microg/L or (ii) CK-MB > 100 microg/L. RESULTS: Of the 50 patients studied, 6 met the criteria for PMI (12%); 2 by criteria (i) and 4 by criteria (ii). In patients not meeting the criteria for MI the troponin I level peaked at 7 hour post-op with a mean of 20.97 microg/L (95% CI,17.11 to 24.83). At this time, patients who met the criteria for MI had a mean troponin I level of 46.85 microg/L (95% CI, 36.40 to 57.30). Of variables investigated for the 44 patients who did not meet MI criteria, only preoperative troponin I level impacted peak postoperative troponin I. CONCLUSIONS: CABG elevates troponin I far beyond current diagnostic benchmarks without the clinical occurrence of a MI and appears to peak during the second postoperative day. An elevated preoperative troponin I may predict an elevated peak postoperative troponin I in patients who do not have a PMI.
机译：背景：肌钙蛋白I用于诊断心肌梗塞（MI）。在冠状动脉搭桥术（CABG）手术中，它的使用和抬高模式尚不明确。这项研究评估了接受紧急CABG的患者肌钙蛋白I升高的时机。方法：前瞻性研究接受紧急隔离型CABG并进行体外循环的患者。在术前，术后7小时，术后14至18小时，术后30至48小时以及术后第4天采集血样以测量CK，CK-MB和肌钙蛋白I。记录心电图和住院过程。围手术期心肌梗死（PMI）的定义是：（i）在CK-MB升高> 50 microg / L时新的Q波的ECG标准，或（ii）CK-MB> 100 microg / L。结果：在研究的50例患者中，有6例符合PMI标准（12％）。 2个标准（i）和4个标准（ii）。在未达到MI标准的患者中，肌钙蛋白I水平在术后7小时达到峰值，平均为20.97 microg / L（95％CI，17.11至24.83）。此时，符合MI标准的患者的肌钙蛋白I平均水平为46.85 microg / L（95％CI，36.40至57.30）。在对不符合MI标准的44例患者进行的调查变量中，只有术前肌钙蛋白I水平会影响术后肌钙蛋白I峰值。术后一天。术前肌钙蛋白I升高可预示无PMI的患者术后肌钙蛋白I峰值升高。

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