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首页> 外文期刊>Journal of cardiac failure >Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis
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Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis

机译：微生物组和心力衰竭之间的交叉：重新审视肠道假说。

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摘要

Microbes play an important role in human health and disease. In the setting of heart failure (HF), substantial hemodynamic changes, such as hypoperfusion and congestion in the intestines, can alter gut morphology, permeability, function, and possibly the growth and composition of gut microbiota. These changes can disrupt the barrier function of the intestines and exacerbate systemic inflammation via microbial or endotoxin translocation into systemic circulation. Furthermore, cardiorenal alterations via metabolites derived from gut microbiota can potentially mediate or modulate HF pathophysiology. Recently, trimethylamine N-oxide (TMAO) has emerged as a key mediator that provides a mechanistic link between gut microbiota and multiple cardiovascular diseases, including HF. Potential intervention strategies which may target this microbiota-driven pathology include dietary modification, prebiotics/probiotics, and selective binders of microbial enzymes or molecules, but further investigations into their safety and efficacy are warranted.
机译：微生物在人类健康和疾病中起着重要作用。在心力衰竭（HF）的情况下，肠道的血流动力学变化（例如灌注不足和充血）可能会改变肠道形态，通透性，功能，甚至可能改变肠道菌群的生长和组成。这些变化可破坏肠道的屏障功能，并通过微生物或内毒素易位进入全身循环而加剧全身炎症。此外，经由源自肠道菌群的代谢物的心肾改变可潜在地介导或调节HF病理生理。近来，三甲胺N-氧化物（TMAO）已成为关键的介体，在肠道菌群与包括HF在内的多种心血管疾病之间建立了机械联系。可能针对这种微生物引起的病理学的潜在干预策略包括饮食改良，益生元/益生菌以及微生物酶或分子的选择性结合剂，但是有必要对其安全性和有效性进行进一步研究。

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