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首页> 外文期刊>Journal of cardiac surgery. >Biological mechanisms influencing the function of the aortic root.
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Biological mechanisms influencing the function of the aortic root.

机译：影响主动脉根功能的生物学机制。

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摘要

Optimal function of the aortic root relies upon the ability of its component structures to move in a coordinated fashion. Some of the cells that make up the structures of the aortic root have been shown to contain nerves, receptors, and contractile elements. The ability to contract or relax may contribute to the successful function of the valve by allowing it to move in a coordinated manner in response to biological stimuli. It is known that cusp tissue receives primary, sensory, and autonomic nerves, suggesting a role for neuronal regulation of cusp function. In addition, cusp tissue has been shown to express a wide variety of receptors and to contract to a range of common vasoactive agents. The cells that constitute the valve have also shown secretory and proliferative responses. The biological signals that mediate the cross-talk between the different parts of the root have not been established. This review will examine the mechanisms that have been documented to be present and to assess their potential contribution in affecting aortic valve function.
机译：主动脉根的最佳功能依赖于其组成结构以协调方式运动的能力。已经证明构成主动脉根结构的某些细胞含有神经，受体和收缩成分。收缩或放松的能力可以通过允许瓣膜响应于生物刺激而协调地运动来促进瓣膜的成功功能。众所周知，尖瓣组织接受原神经，感觉神经和自主神经，提示神经元调节尖瓣功能。另外，已经显示出尖瓣组织表达多种受体并收缩至一系列常见的血管活性剂。构成瓣膜的细胞也显示出分泌和增殖反应。尚未建立介导根的不同部分之间的串扰的生物学信号。这项审查将检查已被证明存在的机制，并评估它们在影响主动脉瓣功能中的潜在作用。

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