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首页> 外文期刊>Journal of cardiac surgery. >Adrenomedullin: a cardiac depressant factor in septic shock.
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Adrenomedullin: a cardiac depressant factor in septic shock.

机译：肾上腺髓质素：败血性休克的心脏抑制因子。

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Despite intensive research, septic shock is still the most common cause of death in surgical intensive care, and its incidence keeps increasing. No curative treatment is yet available. The critical aspect of septic shock is the refractory hypotension that develops during its late phase which leads to a progressive deterioration of cell and organ functions, and in most instances, death. During septic shock, following the overproduction of cytokines, many factors such as nitric oxide and adrenomedullin (ADM) are produced in abnormally large quantities, but our understanding of their contribution to the pathophysiology of sepsis is limited. Here we show that adrenomedullin (22-52), an adrenomedullin receptor antagonist, improves the contractility of myocytes isolated from lipopolysaccharide (LPS)-treated rats, whereas in normal myocytes, adrenomedullin, acting through an adrenomedullin (22-52) sensitive receptor, decreases their contractility. In addition, adrenomedullin antiserum and inducible nitric oxide (NO) synthase inhibitor improve the survival of LPS-treated rats. The data indicate that adrenomedullin is a cardiac depressant factor, which along with NO precipitates ventricular failure during septic shock.
机译：尽管进行了深入研究，败血性休克仍然是外科重症监护病房中最常见的死亡原因，并且其发生率一直在增加。尚无治疗方法。败血性休克的关键方面是难治性低血压，其发生在晚期，导致细胞和器官功能的逐步恶化，并在大多数情况下导致死亡。在败血性休克期间，由于细胞因子的过量产生，大量产生了诸如一氧化氮和肾上腺髓质素（ADM）等许多因子，但我们对它们对败血症的病理生理学贡献的了解有限。在这里，我们显示肾上腺髓质素（22-52）是一种肾上腺髓质素受体拮抗剂，可改善从脂多糖（LPS）处理的大鼠中分离出的心肌细胞的收缩力，而在正常的心肌细胞中，肾上腺髓质素通过肾上腺髓质素（22-52）敏感受体发挥作用，降低其收缩力。此外，肾上腺髓质素抗血清和诱导型一氧化氮（NO）合酶抑制剂可改善LPS治疗大鼠的存活率。数据表明肾上腺髓质素是心脏抑制因子，它与NO一起导致败血性休克期间的心室衰竭。

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