...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cardiac surgery. >Pretransplant diabetes, not donor age, predicts long-term outcomes in cardiac transplantation.
【24h】

Pretransplant diabetes, not donor age, predicts long-term outcomes in cardiac transplantation.

机译：移植前糖尿病（而非供体年龄）可预测心脏移植的长期结果。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Aim: Accepting donors of advanced age may increase the number of hearts available for transplantation. Objectives were to review the outcomes of using cardiac donors 50 years of age and older and to identify predictors of outcome at a single institution. Methods: A retrospective analysis of all adult cardiac transplants (n = 338) performed at our institution between 1988 and 2002 was conducted. Results: Of these, 284 patients received hearts from donors <50 years old and 54 received hearts from donors >/=50 years old. Recipients of hearts from older donors had a greater frequency of pretransplant diabetes (19% vs 33%), renal failure (16% vs 30%), and dialysis (3% vs 9%). There were no differences in ICU or postoperative length of stay, days ventilated, or early rejection episodes. Recipients of older donor hearts, however, had increased perioperative mortality (7% vs 17%; p = 0.03). Multivariate analysis identified older donors (OR 2.599; p = 0.03) and donor ischemia time (OR 1.006; p = 0.002) as significant predictors of perioperative mortality. Actuarial survival at 1 (87% vs 74%), 5 (76% vs 69%), and 10 (59% vs 58%) years was similar (p = 0.08) for the two groups. Separate multivariate analyses identified pretransplant diabetes as the sole predictor of long-term survival (HR 1.659; p = 0.02) and transplant coronary disease (HR 2.486; p = 0.003). Conclusions: Despite increased perioperative mortality, donors >/=50 years old may be used with long-term outcomes similar to those of younger donor hearts. This has potential to expand the donor pool. Pretransplant diabetes has a significant impact on long-term outcomes in cardiac transplantation and requires further investigation.
机译：背景与目的：接受高龄捐赠者可能会增加可移植心脏的数量。目的是审查使用50岁及50岁以上的心脏供体的结果，并确定单个机构的结果预测因子。方法：回顾性分析我院1988年至2002年间进行的所有成人心脏移植手术（n = 338）。结果：其中，有284例患者接受了50岁以下的捐献者的心脏，其中54例接受了50岁以上的捐献者的捐献。年龄较大的捐献者的心脏接受者发生移植前糖尿病的频率更高（19％对33％），肾衰竭（16％对30％）和透析（3％对9％）。 ICU或术后住院时间，通气天数或早期排斥反应发作均无差异。然而，较老的供体心脏接受者的围手术期死亡率增加（7％vs 17％; p = 0.03）。多变量分析确定较年长的供体（OR 2.599; p = 0.03）和供体缺血时间（OR 1.006; p = 0.002）是围手术期死亡率的重要预测指标。两组的1年（87％vs 74％），5年（76％vs 69％）和10年（59％vs 58％）的精算生存率相似（p = 0.08）。单独的多变量分析确定了移植前糖尿病是长期存活（HR 1.659; p = 0.02）和移植性冠心病（HR 2.486; p = 0.003）的唯一预测因素。结论：尽管围手术期死亡率增加，但> / = 50岁的供体仍可长期使用，与年轻的供体心脏相似。这有可能扩大捐助者的数量。移植前糖尿病对心脏移植的长期结果具有重大影响，需要进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号