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首页> 外文期刊>Journal of cardiac surgery. >Mechanics of the normal heart.
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Mechanics of the normal heart.

机译：正常心脏的力学。

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Even though studies on isolated papillary muscles and cardiomyocytes can be applied to the mechanics of a beating heart, it is not always easy for physicians to relate these findings to clinical medicine. Thus, it is important to extend the studies to intact heart either in simulations or in animal models and even better to validate the results with human subjects. Advances in engineering and computer technology have allowed us to bridge the gap between physiology and mechanics. Cardiomyocyte stress/strain relates to muscle energy expenditure, which dictates oxygen and substrate utilization. Appreciation of this sequential relationship by clinicians will facilitate the logical development and assessment of therapies. Theory of finite element analysis (FEA) can predict cardiac mechanics under normal and pathologic conditions. Imaging studies provide an avenue to relate these predictions indirectly to experimental studies. In this fashion, we can understand the mechanical basis for the micro- and macroanatomical twisting motion of the beating heart. The purposes of this manuscript are: (1) to examine the terms that are traditionally used to describe mechanical stresses and strain within the ventricle, (2) to explore the three-dimensional organization of cardiomyocytes that influences global ventricular function, (3) to apply mechanical measures to both single cardiomyofibrils and the intact ventricle (4) to evaluate mathematical and computer models used to characterize cardiac mechanics, and (5) to outline the clinical methods available to measure ventricular function and relate findings from FEA to pathologic conditions.
机译：即使对孤立的乳头状肌和心肌细胞的研究可以应用于跳动的心脏力学，但医生并不总是很容易将这些发现与临床医学联系起来。因此，重要的是在模拟或动物模型中将研究扩展到完整的心脏，甚至更好地与人类受试者一起验证结果。工程和计算机技术的进步使我们能够弥合生理学和力学之间的鸿沟。心肌压力/应变与肌肉能量消耗有关，肌肉能量消耗决定了氧气和底物的利用率。临床医生对这种顺序关系的欣赏将促进逻辑的发展和疗法的评估。有限元分析（FEA）理论可以预测正常和病理情况下的心脏力学。影像学研究提供了将这些预测与实验研究间接联系起来的途径。通过这种方式，我们可以了解跳动的心脏的微观和宏观解剖扭曲运动的机械基础。该手稿的目的是：（1）检查传统上用来描述脑室内机械应力和应变的术语，（2）探索影响整体心室功能的心肌细胞的三维组织，（3）将机械措施应用于单个心肌原纤维和完整的心室（4）评估用于表征心脏力学的数学和计算机模型，以及（5）概述可用于测量心室功能的临床方法并将FEA的发现与病理状况联系起来。

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