...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of cardiac surgery. >Effect of induction therapy on kinetic of procalcitonin following uncomplicated heart transplantation.
【24h】

Effect of induction therapy on kinetic of procalcitonin following uncomplicated heart transplantation.

机译：单纯心脏移植术后诱导疗法对降钙素动力学的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: The aim of the study was to determine the early postoperative kinetics of serum procalcitonin (PCT) levels in uncomplicated heart transplant patients under induction therapy using antithymocyte globulin (ATG). METHODS: PCT serum concentrations were measured for 7 days in 30 adult patients (26 males, 4 females, mean age 54.5 +/- 7.7 years) undergoing uncomplicated orthotopic heart transplantation. Of the 30 patients, 28 received ATG and 2 with the same immunosuppression regimen had no induction therapy. The induction therapy consisted of 100 mg/day ATG and was started 6 hours postoperatively. RESULTS: Mean PCT levels immediately before HTX were <0.3 ng/mL in both groups. After the first ATG infusion patients developed a significant (p < 0.05) elevation in PCT plasma levels without any incidence of infectious disease with peak levels up to 11.7 +/- 19.7 ng/mL on postoperative day (POD) 1. Thereafter values continuously decreased independently of further ATG administration in all patients (6.7+/- 10.5 ng/mL on POD 3, 3.2 +/- 7.4 ng/mL on POD 5 and 1.2 +/- 3.0 ng/mL on POD 7). In the non-ATG group a mild postoperative rise in the serum PCT was observed. The values peaked on POD 2 with 2.0 +/- 1.6 ng/mL and normalized within four days. CONCLUSIONS: Perioperative administration of ATG is associated with significantly increased PCT levels even in uncomplicated heart transplant recipients. This phenomenon should not be misinterpreted as systemic infection, as systemic inflammatory reaction that seems to be induced by ATG therapy is responsible for increased PCT production.
机译：背景：这项研究的目的是确定使用抗胸腺细胞球蛋白（ATG）进行诱导治疗的单纯性心脏移植患者的血清降钙素原（PCT）水平的早期术后动力学。方法：对30例接受单纯性原位心脏移植手术的成年患者（26例男性，4例女性，平均年龄54.5 +/- 7.7岁）的PCT血清浓度进行了7天的测量。在30例患者中，有28例接受了ATG，2例采用相同的免疫抑制方案未接受诱导治疗。诱导疗法由100 mg / day ATG组成，在术后6小时开始。结果：两组HTX之前的平均PCT水平<0.3 ng / mL。首次ATG输注后，患者的PCT血浆水平显着升高（p <0.05），无任何感染性疾病的发生，术后第1天（POD）的峰值水平达到11.7 +/- 19.7 ng / mL。此后数值持续下降在所有患者中均独立于进一步的ATG给药（POD 3为6.7 +/- 10.5 ng / mL，POD 5为3.2 +/- 7.4 ng / mL，POD 7为1.2 +/- 3.0 ng / mL）。在非ATG组中，观察到术后血清PCT轻度升高。该值在POD 2上达到2.0 +/- 1.6 ng / mL的峰值，并在四天内标准化。结论：ATG的围手术期给药与PCT水平显着升高有关，即使在没有并发症的心脏移植受者中也是如此。不应将这种现象误认为是全身性感染，因为似乎由ATG治疗诱导的全身性炎症反应可导致PCT产生增加。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号