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首页> 外文期刊>Journal of cardiac surgery. >BioGlue: a protective barrier after pericardiotomy.
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BioGlue: a protective barrier after pericardiotomy.

机译：BioGlue：心包切开术后的保护性屏障。

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BACKGROUND: Repeat operation on the heart composes about 20% of procedures in contemporary practice of cardiac surgery. A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. METHODS: Anterior pericardiectomy was performed in rats. BioGlue milled to a 0.4 mm sheet was applied to the anterior surface of the heart in 16 rats; Surgicel plus liquid BioGlue in seven; Surgicel alone in three; and nothing (control) in eight. The operative site was reexamined for gross evidence of adhesion, scarring, and residual BioGlue 1, 3, and 6 months later. RESULTS: There was formation of a loose connective tissue barrier containing blood vessels without scar formation in all animals treated with milled BioGlue. Surgicel plus BioGlue resulted in a barrier containing more denser connective tissue with collagen fibers. Surgicel alone resulted in a similar barrier. No barrier formed in the control experiments. CONCLUSIONS: A sheet of milled BioGlue applied over the surface of theheart but not attached to it after partial pericardiectomy has been shown to stimulate formation of a loose connective tissue barrier containing blood vessels. This barrier is unique compared to dense fibrous scar which usually forms after opening the pericardium for cardiac operations.
机译：背景：在现代心脏外科手术中，对心脏的重复手术约占手术的20％。提供阻止心脏粘附到胸骨的屏障的材料片将是期望的。方法：对大鼠进行前心包切除术。将研磨成0.4毫米薄片的BioGlue应用于16只大鼠的心脏前表面; Surgicel加液体BioGlue七次; Surgicel单独服用三分八分之内没有（控制）。 1、3和6个月后，再次检查手术部位的粘连，疤痕和残留的BioGlue的总体证据。结果：在所有经过研磨的BioGlue处理的动物中，均形成了一个疏松的结缔组织屏障，其中包含血管，而没有疤痕形成。 Surgicel加BioGlue产生了一个屏障，该屏障包含具有胶原纤维的更密集的结缔组织。单独使用Surgicel会导致类似的障碍。在对照实验中没有形成屏障。结论：局部心包切除术后，将一块磨碎的生物胶涂在心脏表面，但未附着在心脏表面，可刺激形成包含血管的疏松结缔组织屏障。与通常在打开心包进行心脏手术后形成的密集纤维疤痕相比，该屏障是独特的。

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