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首页> 外文期刊>Journal of cardiology >Plaque stabilization by intensive LDL-cholesterol lowering therapy with atorvastatin is delayed in type 2 diabetic patients with coronary artery disease-Serial angioscopic and intravascular ultrasound analysis
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Plaque stabilization by intensive LDL-cholesterol lowering therapy with atorvastatin is delayed in type 2 diabetic patients with coronary artery disease-Serial angioscopic and intravascular ultrasound analysis

机译：阿托伐他汀强化LDL-胆固醇降低疗法的牙菌斑稳定作用在2型糖尿病合并冠状动脉疾病的糖尿病患者中得到了应用-串行血管内和血管内超声分析

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Background: Diabetes mellitus (DM) is a major risk factor for cardiovascular events. The study purpose was to compare DM and non-DM (nDM) patients in terms of statin-induced change of plaque characteristics using intravascular ultrasound (IVUS) and coronary angioscopy. Methods: Patients with coronary artery disease and hypercholesterolemia who were enrolled to the TWINS were selected and classified into two groups: DM group and nDM group. Eleven DM patients and 28 nDM patients were studied. Results: Low-density lipoprotein cholesterol levels decreased significantly to a similar extent at weeks 28 and 80 from baseline in DM and nDM (p< 0.001). The mean angioscopic color grades of yellow plaques in DM and nDM were similar at baseline and significantly decreased at week 80 from baseline in both groups, however, the mean change of angioscopic color grade from baseline in DM were not significantly decreased and the mean angioscopic color was significantly higher than that in nDM (1.34 vs. 1.00, p< 0.05) at week 28. IVUS showed plaque volume reduction in both groups (p< 0.01) except at week 80 in DM group, which was not statistically significant different compared to the baseline. Conclusion: In DM patients, plaque volume regression by atorvastatin was shown to be attenuated, and its color improvement was significantly delayed. However, the yellowness became comparable between DM and nDM groups at week 80. These results indicate that patients with DM should be treated by intensive lipid-lowering therapy with atorvastatin for at least 80 weeks to stabilize vulnerable plaque.
机译：背景：糖尿病（DM）是心血管事件的主要危险因素。本研究的目的是通过血管内超声（IVUS）和冠状动脉血管镜检查比较他汀类药物引起的斑块特征变化方面的DM和非DM（nDM）患者。方法：选择入选TWINS的冠心病和高胆固醇血症患者，将其分为两组：DM组和nDM组。研究了11名DM患者和28名nDM患者。结果：DM和nDM患者的低密度脂蛋白胆固醇水平在第28周和第80周时均较基线水平显着下降（p <0.001）。 DM和nDM的黄色斑块的平均血管镜显色等级在基线时相似，并且在第80周时均较基线显着降低，但是，DM的基线的血管镜显色等级的平均变化并没有显着降低，并且平均血管镜显色在第28周时显着高于nDM​​（1.34 vs. 1.00，p <0.05）。IVUS显示两组的斑块体积减少（p <0.01），但DM组在第80周时与统计学相比无统计学差异。基线。结论：在DM患者中，阿托伐他汀可减轻斑块体积，其颜色改善明显延迟。然而，在第80周时，DM组和nDM组之间的黄度变得可比。这些结果表明，DM患者应接受阿托伐他汀强化降脂治疗至少80周，以稳定易损斑块。

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