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Optical coherence tomography of the pulmonary arteries: A systematic review

机译：肺动脉光学相干断层扫描：系统评价

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Optical coherence tomography (OCT) is an imaging technique extensively used for visualizing the coronary circulation, where it assists clinical decision-making. Along with the new interventional procedures being introduced for pulmonary vascular disease, there is an increasing need for intravascular imaging of the pulmonary arteries. Additionally, measurements of the wall thickness of the pulmonary arteries of patients with various types of pulmonary hypertension (PH) may provide relevant diagnostic and prognostic information. The aim of this review is to summarize all the available evidence on the use of OCT for imaging the pulmonary bed and to describe a simple protocol for OCT image acquisition. We conducted a systematic review of the literature using electronic reference databases through February 2015 (MEDLINE, Cochrane Library, Web of Knowledge, and references cited in other studies) and the search terms "optical coherence tomography," "pulmonary hypertension," and "pulmonary arteries." Studies in which OCT was used to image the pulmonary vessels were considered for inclusion. We identified 14 studies reporting OCT imaging data from the pulmonary arteries. OCT was able to identify intravascular thrombi in patients with chronic thromboembolic PH (CTEPH), and an increase in vessel wall thickness was found in most patients with PH, compared with the controls. OCT has also been reported to be useful for the selection of balloon size in the setting of balloon pulmonary angioplasty for CTEPH. The main limitations include lack of standardization, little data on outcomes, cost, and the technical limitations involved in visualizing small-diameter (<1 mm) pulmonary vessels. OCT has become a potential tool for the in vivo study of vascular changes in the pulmonary arteries, and may provide additional information in the assessment of patients with PH. Prospective high-quality studies assessing the safety, validity, and clinical impact of OCT imaging for pulmonary vessels are warranted. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
机译：光学相干断层扫描（OCT）是广泛用于可视化冠状动脉循环的成像技术，可协助临床决策。随着引入针对肺血管疾病的新的介入程序，对肺动脉的血管内成像的需求日益增加。另外，对各种类型的肺动脉高压（PH）患者的肺动脉壁厚度的测量可能会提供相关的诊断和预后信息。这篇综述的目的是总结有关使用OCT进行肺床成像的所有可用证据，并描述用于OCT图像采集的简单协议。我们在2015年2月之前使用电子参考数据库（MEDLINE，Cochrane图书馆，Web of Knowledge和其他研究引用的参考文献）以及搜索词“光学相干断层扫描”，“肺动脉高压”和“肺动脉。”考虑使用OCT对肺血管成像的研究包括在内。我们确定了14项研究报告了来自肺动脉的OCT成像数据。 OCT能够鉴定慢性血栓栓塞性PH（CTEPH）患者的血管内血栓，并且与对照组相比，大多数PH患者发现血管壁厚度增加。据报道，在CTEPH的球囊肺血管成形术中，OCT可用于选择球囊大小。主要局限性包括缺乏标准化，关于结果，成本的数据很少，以及在可视化小直径（<1 mm）肺血管方面涉及的技术局限性。 OCT已成为体内研究肺动脉血管变化的潜在工具，并可能在评估PH患者中提供更多信息。评估OCT成像对肺血管的安全性，有效性和临床影响的前瞻性高质量研究是必要的。 （C）2015年日本心脏病学会。由Elsevier Ltd.出版。保留所有权利。

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