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首页> 外文期刊>Journal of cardiology >Cardioprotective mechanism of omega-3 polyunsaturated fatty acids
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Cardioprotective mechanism of omega-3 polyunsaturated fatty acids

机译：Omega-3多不饱和脂肪酸的心脏保护机制

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摘要

Omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid and docosahexaenoic acid, are widely regarded as cardioprotective. Several large-scale, randomized clinical trials have shown that dietary intake of omega-3 PUFAs improves the prognosis of patients with symptomatic heart failure or recent myocardial infarction. Therefore, dietary consumption of omega-3 PUFA is recommended in international guidelines for the general population to prevent the occurrence of cardiovascular diseases (CVD5). However, the precise mechanisms underlying the cardioprotective effects of omega-3 PUFAs are not fully understood. Omega-3 PUFAs can be incorporated into the phospholipid bilayer of cell membranes and can affect membrane fluidity, lipid microdomain formation, and signaling across membranes. Omega-3 PUFAs also modulate the function of membrane ion channels, such as Na and L-type Ca channels, to prevent lethal arrhythmias. Moreover, omega-3 PUFAs also prevent the conversion of arachidonic acid into pro-inflammatory eicosanoids by serving as an alternative substrate for cyclooxygenase or lipoxygenase, resulting in the production of less potent products. In addition, a number of enzymatically oxygenated metabolites derived from omega-3 PUFAs were recently identified as anti-inflammatory mediators. These omega-3 metabolites may contribute to the beneficial effects against CVDs that are attributed to omega-3 PUFAs. (C) 2015 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
机译：Omega-3多不饱和脂肪酸（PUFA），如二十碳五烯酸和二十二碳六烯酸，被广泛认为具有心脏保护作用。几项大规模的随机临床试验表明，饮食中摄入omega-3 PUFA可以改善有症状心力衰竭或近期心肌梗塞的患者的预后。因此，在国际指南中建议一般人群饮食中摄入omega-3 PUFA，以预防心血管疾病（CVD5）的发生。但是，尚未完全了解omega-3 PUFA心脏保护作用的确切机制。 Omega-3 PUFA可以掺入细胞膜的磷脂双层中，并且可以影响膜的流动性，脂质微区的形成以及跨膜的信号传导。 Omega-3 PUFA还可以调节膜离子通道（例如Na和L型Ca通道）的功能，以防止致死性心律失常。此外，omega-3 PUFA还可以用作环氧合酶或脂氧合酶的替代底物，从而防止花生四烯酸转化为促炎性类花生酸，从而导致产生效力较低的产品。此外，近来已鉴定出许多源自omega-3 PUFA的酶促氧化代谢产物作为抗炎介质。这些omega-3代谢产物可能有助于抵抗归因于omega-3 PUFA的CVD的有益作用。 （C）2015年日本心脏病学会。由Elsevier Ltd.出版。保留所有权利。

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