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首页> 外文期刊>Journal of cardiology >Assessment of left ventricular diastolic function with pioglitazone in type 2 diabetic patients
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Assessment of left ventricular diastolic function with pioglitazone in type 2 diabetic patients

机译：吡格列酮评估2型糖尿病患者左室舒张功能

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OBJECTIVES: This study investigated the effect of pioglitazone, an insulin sensitizer, on left ventricular diastolic function in type 2 diabetic patients. METHODS: Various echocardiographic parameters such as left ventricular ejection fraction, transmitral E/A ratio (E/A), deceleration time of E, isovolumetric relaxation time and left ventricular Tei index were measured. A total of 59 patients were enrolled in the ON-group, and the parameters were examined before and after pioglitazone administration (15-30 mg/day) for 6 months, and 9 patients in the OFF-group, and the parameters were examined before and 6 months after cessation of pioglitazone. RESULTS: Average age of subjects was 61.5 years with an age range from 45 to 79 years. Left ventricular ejection fraction and brain natriuretic peptide were not significantly changed both in the ON-group and in the OFF-group. Pioglitazone significantly increased E/A (0.91 +/- 0.23 vs 0.99 +/- 0.24, p < 0.01)and decreased deceleration time of E (233.9 +/- 58.6 vs 209.9 +/- 38.3 msec, p < 0.01), isovolumetric relaxation time(91.5 +/- 13.6 vs 76.0 +/- 12.1 msec, p < 0.01)and left ventricular Tei index (0.38 +/- 0.11 vs 0.35 +/- 0.09, p < 0.01) in the ON-group. On the other hand, E/A (1.08 +/- 0.35 vs 0.88 +/- 0.20, p < 0.01) was significantly decreased and left ventricular Tei index (0.28 +/- 0.11 vs 0.33 +/- 0.11, p < 0.01) was significantly increased in the OFF-group. CONCLUSIONS: Pioglitazone administration improves and cessation worsens left ventricular diastolic function.
机译：目的：本研究调查了胰岛素增敏剂吡格列酮对2型糖尿病患者左心室舒张功能的影响。方法：测量了各种超声心动图参数，例如左心室射血分数，透射E / A比（E / A），E减速时间，等容松弛时间和左心室Tei指数。共有59例患者被纳入ON组，并在吡格列酮给药（15-30 mg /天）的6个月前后进行了参数检查，而在OFF组中有9例患者在开始之前进行了参数检查吡格列酮停用后6个月。结果：受试者的平均年龄为61.5岁，年龄范围为45至79岁。左心室射血分数和脑钠肽在ON组和OFF组均无明显变化。吡格列酮显着提高E / A（0.91 +/- 0.23 vs 0.99 +/- 0.24，p <0.01）和减少E的减速时间（233.9 +/- 58.6 vs 209.9 +/- 38.3毫秒，p <0.01），等容松弛时间（91.5 +/- 13.6 vs 76.0 +/- 12.1 ms，p <0.01）和ON组左心室Tei指数（0.38 +/- 0.11 vs 0.35 +/- 0.09，p <0.01）。另一方面，E / A（1.08 +/- 0.35 vs 0.88 +/- 0.20，p <0.01）显着降低，左心室Tei指数（0.28 +/- 0.11 vs 0.33 +/- 0.11，p <0.01）在OFF组中明显增加。结论：吡格列酮的使用改善了戒烟症状，使左心室舒张功能恶化。

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