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首页> 外文期刊>Journal of cardiology >Redox imbalance in patients with coronary artery disease showing progression of atherosclerotic lesions.
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Redox imbalance in patients with coronary artery disease showing progression of atherosclerotic lesions.

机译：冠状动脉疾病患者的氧化还原失衡显示动脉粥样硬化病变的进展。

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OBJECTIVES: To clarify the relationship between changes in redox balance and the development of new coronary lesions in patients with coronary artery disease (CAD). METHODS: We studied 82 CAD patients (70 males and 12 females, mean age 61.8 +/- 9.2 years) who underwent repeated coronary angiography within 1 year after percutaneous coronary intervention. Levels of serum lipid peroxide, erythrocyte glutathione peroxidase activity, and the redox state of erythrocyte (ratio of reduced to oxidized glutathione, the GSH/GSSG ratio) were measured at the time of follow-up coronary angiography. According to the development of significant stenotic lesions, we divided the patients into two groups: 57 patients without the development of new stenotic lesions (group A) and 25 patients showing new significant stenotic lesions within 1 year (group B). RESULTS: The serum lipid peroxide level in group B was significantly higher than those of group A (2.61 +/- 0.32 vs 1.74 +/- 0.16 nmol/ml, p < 0.01). Erythrocyte glutathione peroxidase activity did not differ significantly between two groups. The erythrocyte GSH/GSSG ratio in group B was significantly lower than that of group A (83 +/- 9.6 vs 126 +/- 7.3, p < 0.01). The sensitivity and specificity of GSH/GSSG ratio to detect CAD patients with the development of significant coronary stenosis were 80.0% and 61.4%, respectively. CONCLUSIONS: CAD patients who showed development of new coronary lesions within 1 year have increased oxidative stress and imbalanced erythrocyte redox state. The GSH/GSSG ratio, an indicator for redox balance, could be a useful marker to identify high-risk CAD patients.
机译：目的：阐明冠状动脉疾病（CAD）患者氧化还原平衡变化与新冠状动脉病变发展之间的关系。方法：我们研究了82例CAD患者（70例男性和12例女性，平均年龄61.8 +/- 9.2岁），他们在经皮冠状动脉介入治疗后1年内进行了重复冠状动脉造影。在随访冠状动脉造影时，测量血清脂质过氧化物，红细胞谷胱甘肽过氧化物酶活性和红细胞的氧化还原状态（还原性氧化谷胱甘肽的比率，GSH / GSSG比）。根据严重狭窄病变的发展，我们将患者分为两组：57例未出现新狭窄病变的患者（A组）和25例在1年内出现新的严重狭窄病变的患者（B组）。结果：B组的血清脂质过氧化物水平显着高于A组（2.61 +/- 0.32 vs 1.74 +/- 0.16 nmol / ml，p <0.01）。两组之间的红细胞谷胱甘肽过氧化物酶活性没有显着差异。 B组的红细胞GSH / GSSG比明显低于A组（83 +/- 9.6对126 +/- 7.3，p <0.01）。 GSH / GSSG比检测冠状动脉狭窄严重的CAD患者的敏感性和特异性分别为80.0％和61.4％。结论：在1年内显示出新的冠状动脉病变的CAD患者氧化应激增加且红细胞氧化还原状态失衡。 GSH / GSSG比是氧化还原平衡的指标，可能是识别高危CAD患者的有用标志。

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