Dietary measures and exercise training contribute to improvement of endothelial function and atherosclerosis even in patients given intensive pharmacologic therapy.

Chan SY; Mancini GB; Burns S; Johnson FF; Brozic AP; Kingsbury K; Barr S; Kuramoto L; Schulzer M; Frohlich J; Ignaszewski A

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Dietary measures and exercise training contribute to improvement of endothelial function and atherosclerosis even in patients given intensive pharmacologic therapy.

机译：饮食措施和运动训练甚至在接受强化药物治疗的患者中也有助于改善内皮功能和动脉粥样硬化。

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PURPOSE: Atherosclerosis contributes to cardiovascular mortality and morbidity even with aggressive lipid management. Our objective is to determine whether a combined pharmacological and lifestyle intervention can improve atherosclerosis. METHODS: We conducted a 2-year observational study at a specialized clinic in a tertiary care hospital. One hundred fifty-six subjects with coronary disease were enrolled in an intensive pharmacological management and lifestyle measures (including counseling and exercise training) program designed to reach specific targets. The main outcome measures were carotid intima media thickness and plaque area; brachial artery flow-mediated dilation; nitroglycerin-mediated dilation; flow-mediated dilation-nitroglycerin-mediated dilation ratio; laboratory parameters including lipids, glucose, creatinine, and homocysteine; and physical fitness. RESULTS: At completion, there were improvements in lipids and physical fitness. There were no overall changes in flow-mediated dilation, nitroglycerin-mediated dilation, or carotid intima media thickness in the entire cohort. However, multivariate logistic regression showed that dietary and exercise variables, such as increasing fiber intake and reducing body weight and body fat percentage, were independent predictors of improvements in endothelial function and carotid plaque burden. CONCLUSIONS: Even in the setting of intensive pharmacological therapy, lifestyle interventions, including exercise training and dietary changes, are important determinants of improved endothelial function and atherosclerosis.

机译：目的：即使进行积极的脂质管理，动脉粥样硬化也会导致心血管疾病的死亡率和发病率。我们的目标是确定药理和生活方式综合干预措施能否改善动脉粥样硬化。方法：我们在一家三级护理医院的专门诊所进行了为期两年的观察性研究。 156名患有冠心病的受试者参加了旨在达到特定目标的强化药理学管理和生活方式措施（包括咨询和运动培训）计划。主要结局指标为颈动脉内膜中层厚度和斑块面积。肱动脉血流介导的扩张;硝酸甘油介导的扩张;流量介导的扩张-硝酸甘油介导的扩张比;实验室参数包括脂质，葡萄糖，肌酐和高半胱氨酸;和身体健康。结果：完成后，血脂和体质有所改善。在整个队列中，血流介导的扩张，硝酸甘油介导的扩张或颈动脉内膜中层厚度没有整体变化。然而，多元逻辑回归分析显示，饮食和运动变量，例如增加纤维摄入量，降低体重和体脂百分比，是内皮功能和颈动脉斑块负担改善的独立预测因子。结论：即使在强化药物治疗的情况下，生活方式干预，包括运动训练和饮食变化，也是改善内皮功能和动脉粥样硬化的重要决定因素。

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《Journal of cardiopulmonary rehabilitation》 |2006年第5期|共6页
作者
Chan SY; Mancini GB; Burns S; Johnson FF; Brozic AP; Kingsbury K; Barr S; Kuramoto L; Schulzer M; Frohlich J; Ignaszewski A;
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正文语种 eng
中图分类内科学;
关键词
Pathological Dilatation; Exercise; Atherosclerosis; Training; physiological aspects; 运动(Exercise); 动脉粥样硬化;

机译：Pathological Dilatation;Exercise;Atherosclerosis;Training;physiological aspects;运动(Exercise);动脉粥样硬化;

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1. Dietary measures and exercise training contribute to improvement of endothelial function and atherosclerosis even in patients given intensive pharmacologic therapy. [J] . Chan SY, Mancini GB, Burns S, Journal of cardiopulmonary rehabilitation . 2006,第5期

机译：饮食措施和运动训练甚至在接受强化药物治疗的患者中也有助于改善内皮功能和动脉粥样硬化。
2. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats [J] . DolinskyV.W., JonesK.E., SidhuR.S., The Journal of Physiology . 2012,第11期

机译：白藜芦醇在运动训练中引起的骨骼肌力量和心功能的改善有助于增强大鼠的运动表现
3. Exercise training-induced different improvement profile of endothelial progenitor cells function in mice with or without myocardial infarction [J] . Guo Yuan, Peng Ran, Liu Qiong, International Journal of Cardiology . 2016,第Null期

机译：运动训练诱导的小鼠内皮祖细胞功能的不同改善谱，或没有心肌梗死
4. Aquatic exercise training improve physiological adaptation and endothelial function in the elderly type 2 diabetic patients [C] . Natamonwarakul A., Supathra A. Suksom D. Asian Congress for Microcirculation . 2011

机译：水生运动训练改善了老年2型糖尿病患者的生理适应和内皮功能
5. Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide. Pharmacologic administration of lipoic acid partially restores function. [D] . Smith, Anthony R. 2005

机译：神经酰胺水平升高与血管内皮一氧化氮的衰老相关。硫辛酸的药理管理可部分恢复功能。
6. Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats [O] . Vernon W Dolinsky, Kelvin E Jones, Robinder S Sidhu, 2012

机译：白藜芦醇在运动训练过程中引起的骨骼肌力量和心功能的改善有助于增强大鼠的运动表现
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Dietary measures and exercise training contribute to improvement of endothelial function and atherosclerosis even in patients given intensive pharmacologic therapy.

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