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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Immunohistochemical study on VEGF expression in endometrial carcinoma--comparison with p53 expression, angiogenesis, and tumor histologic grade.
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Immunohistochemical study on VEGF expression in endometrial carcinoma--comparison with p53 expression, angiogenesis, and tumor histologic grade.

机译：子宫内膜癌中VEGF表达的免疫组织化学研究-与p53表达，血管生成和肿瘤组织学分级比较。

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OBJECTIVE: Vascular endothelial growth factor (VEGF)--that activates endothelial cell growth--has been considered to induce angiogenesis, which is indispensable to tumor-genesis and progression. In this study, an immunohistochemical analysis was carried out to clarify the correlation of VEGF expression with angiogenesis, p53 expression--of which the wild-type is considered to suppress VEGF expression--and histologic grade in endometrial carcinoma. STUDY DESIGN: Immunohistochemical staining for detecting VEGF protein, factor VIII-related antigen of endothelial cells, and p53 protein was performed by the labeled streptavidin-biotin method on the formalin-fixed and paraffin-embedded tumor tissue of 104 patients with endometrial (endometrioid) carcinoma, including 69 with well-differentiated, 25 with moderately differentiated, and ten with poorly differentiated adenocarcinoma. RESULTS: The labeling index of p53 expression was 19.9+/-28.8% in the high VEGF group, whereas in the low VEGF group it was 12.2+/-17.0%, showing that VEGF expression was significantly correlated with p53 expression (P<0.05). VEGF expression, however, was not correlated with either the number of microvessels in the tumor area or tumor histologic grade. CONCLUSION: VEGF expression was not a single specific indicator of angiogenesis in endometrial carcinoma, whereas it was significantly correlated with p53 expression.
机译：目的：激活血管内皮细胞生长的血管内皮生长因子（VEGF）被认为可诱导血管生成，这对于肿瘤的发生和发展是必不可少的。在这项研究中，进行了免疫组织化学分析，以阐明子宫内膜癌中VEGF表达与血管生成，p53表达（其中野生型被认为抑制VEGF表达）和血管生成的相关性。研究设计：对104例子宫内膜（子宫内膜样）患者进行福尔马林固定和石蜡包埋的肿瘤组织，采用标记的链霉亲和素-生物素方法，进行了免疫组织化学染色，检测VEGF蛋白，内皮细胞与VIII因子相关的抗原和p53蛋白。包括高分化癌69例，中分化癌25例和低分化腺癌的10例。结果：高VEGF组p53表达的标记指数为19.9 +/- 28.8％，低VEGF组为12.2 +/- 17.0％，表明VEGF表达与p53表达显着相关（P <0.05 ）。然而，VEGF表达与肿瘤区域中的微血管数量或肿瘤组织学分级均无关。结论：VEGF的表达不是子宫内膜癌血管生成的单一特异性指标，而与p53表达显着相关。

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