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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Does regular zoledronic acid change the bone turnover of the jaw in men with metastatic prostate cancer: A possible clue to the pathogenesis of bisphosphonate related osteonecrosis of the jaw?
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Does regular zoledronic acid change the bone turnover of the jaw in men with metastatic prostate cancer: A possible clue to the pathogenesis of bisphosphonate related osteonecrosis of the jaw?

机译：定期的唑来膦酸会改变患有转移性前列腺癌的男性颌骨的骨转换吗？这可能是双膦酸酯相关性颌骨坏死的发病机制的线索？

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Purpose: To find out whether the most popular pathogenesis hypothesis of the bisphosphonate (BP) related osteonecrosis of the jaw (BRONJ) is comprehensible: (1) is there a higher bone remodeling in the jaw compared with other skeletal sites? (2) Is the bone turnover (BT) of the jaw overly altered after BP intake? (3) Are there gender- or entity-specific differences in BT before and after BP intake? Methods: Bone scintigraphies of 42 patients with prostate cancer were retrospectively analyzed (n = 21 with BP intake; n = 21 no BP). All patients received bone scintigraphy prior to the therapy and in the course of the treatment (after 12 and 24 months). Data were quantitatively analyzed using six predetermined regions of interest and compared with a breast cancer cohort. Results: The mandible revealed a similar BT as the femur and a significant lower BT compared with the maxilla. All investigated bone regions showed no significant changes under BP administration. Inter-gender differences revealed significantly lower BT values for the prostate cancer compared with the female breast cancer cohort, changes over the course of time could not be found. Conclusions: The finding that the mandible revealed a significant lower BT than the maxilla and the fact that 2/3 of the BRONJ cases occur in the mandible are inconsistent with the investigated hypothesis. Furthermore, the BT in the jawbone is not overly suppressed by BP. Thus, it seems implausible that a high BT and its over-suppression play the key role in the pathomechanism of BRONJ.
机译：目的：了解与双膦酸盐（BP）相关的颌骨坏死（BRONJ）的最流行的发病机理假说是否可理解：（1）与其他骨骼部位相比，颌骨中的骨骼重塑更高吗？ （2）摄入BP后下颌的骨转换（BT）是否过度改变？ （3）在服用BP前后，BT中是否存在性别或个体差异？方法：回顾性分析42例前列腺癌患者的骨闪烁显像（n = 21，有BP摄入; n = 21，无BP）。所有患者在治疗前和治疗过程中（12和24个月后）均接受了骨闪烁显像。使用六个预定的感兴趣区域对数据进行了定量分析，并与乳腺癌队列进行了比较。结果：下颌骨显示出与股骨相似的BT，与上颌骨相比，BT显着降低。在BP给药后，所有研究的骨区域均无明显变化。性别差异表明，与女性乳腺癌队列相比，前列腺癌的BT值显着降低，无法发现其随时间的变化。结论：下颌骨的BT显着低于上颌骨，并且BRONJ病例中有2/3发生在下颌骨中这一事实与所研究的假设不一致。此外，下颌骨中的BT不会被BP过度抑制。因此，高BT及其过度抑制在BRONJ的发病机制中起关键作用似乎是令人难以置信的。

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