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首页> 外文期刊>Journal of Cancer Research and Clinical Oncology >Analysis of HLA-DRB1-related alleles in Japanese patients with lung cancer--relationship to genetic susceptibility and resistance to lung cancer.
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Analysis of HLA-DRB1-related alleles in Japanese patients with lung cancer--relationship to genetic susceptibility and resistance to lung cancer.

机译：日本肺癌患者中HLA-DRB1相关等位基因的分析-与遗传易感性和肺癌抵抗力的关系。

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PURPOSE: To investigate differences in HLA status among lung cancer patients, patients with hematological malignancies, and healthy controls in order to determine the genetic susceptibility and resistance features of HLA-DRB1-related alleles in Japanese patients with lung cancer. METHODS: HLA class I (HLA-A, -B, and -C) antigens and HLA class II (HLA-DRB1) alleles were determined in 36 patients with lung cancer, 35 patients with hematological malignancies, and 90 healthy controls. HLA class I status was investigated by serological techniques, and HLA class II by polymerase chain reaction/restriction-fragment-length polymorphism analysis. RESULTS: Lung cancer patients showed an increased frequency of HLA-DRB1*0901, and a decreased frequency of HLA-DRB1*1302 and DRB1*14-related alleles when compared to the other subjects. CONCLUSION: These results suggest that genetic factors influence the susceptibility and resistance to lung cancer. However, this study should be considered preliminary because of the relatively small number of patients examined and the possibility of racial differences in HLA status of lung cancer patients between Japan and other countries.
机译：目的：调查肺癌患者，血液系统恶性肿瘤患者和健康对照者之间HLA状态的差异，以确定日本肺癌患者HLA-DRB1相关等位基因的遗传易感性和耐药性。方法：在36例肺癌患者，35例血液系统恶性肿瘤患者和90例健康对照者中确定了HLA I类（HLA-A，-B和-C）抗原和HLA II类（HLA-DRB1）等位基因。 HLA I类状态通过血清学技术进行了研究，HLA II类通过聚合酶链反应/限制性片段长度多态性分析进行了研究。结果：与其他受试者相比，肺癌患者的HLA-DRB1 * 0901频率升高，HLA-DRB1 * 1302和DRB1 * 14相关等位基因频率降低。结论：这些结果表明遗传因素影响肺癌的易感性和耐药性。但是，由于研究的患者相对较少，并且日本与其他国家之间的肺癌患者的HLA状况存在种族差异，因此该研究应被视为初步研究。

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