Evaluation of Basal Ganglia and Thalamic Inflammation in Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection and Tourette Syndrome: A Positron Emission Tomographic (PET) Study Using C-11-[R]-PK11195

Kumar Ajay; Williams Mitchel T.; Chugani Harry T.

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Evaluation of Basal Ganglia and Thalamic Inflammation in Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection and Tourette Syndrome: A Positron Emission Tomographic (PET) Study Using C-11-[R]-PK11195

机译：儿童伴链球菌感染和抽动秽语综合症的小儿自身免疫性神经精神疾病的基底节和丘脑炎症的评估：正电子发射断层扫描（PET）研究使用C-11- [R] -PK11195

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We applied PET scanning with C-11-[R]-PK11195 (PK) to evaluate neuroinflammatory changes in basal ganglia and thalamus in children with clinically diagnosed pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) and Tourette syndrome. Seventeen children with PANDAS (mean age: 11.4 +/- 2.6 years; 13 males), 12 with Tourette syndrome (mean age: 11.0 +/- 3.0 years; 10 males), and 15 normal adults (mean age: 28.7 +/- 7.9 years; 8 males) underwent dynamic PK PET imaging and binding potential, a measure of ligand-TSPO receptor (expressed by activated microglia) binding, was calculated for basal ganglia and thalamus. Binding potential values, suggesting underlying activated microglia-mediated neuroinflammation, were found to be increased in bilateral caudate and bilateral lentiform nucleus in the PANDAS group and in bilateral caudate nuclei only in the Tourette syndrome group, compared to control group. These differences in the pattern and extent of neuroinflammation also signify a possible difference in pathophysiological etiology between PANDAS and Tourette syndrome patients.

机译：我们应用C-11- [R] -PK11195（PK）进行PET扫描，以评估患有链球菌感染（PANDAS）和Tourette综合征的临床诊断为儿童自身免疫性神经精神疾病的儿童基底节和丘脑的神经炎性变化。 17名患有PANDAS的儿童（平均年龄：11.4 +/- 2.6岁;男性13名），12名患有图雷特综合症（平均年龄：11.0 +/- 3.0岁; 10名男性）和15名正常成人（平均年龄：28.7 +/-） 7.9岁; 8名男性）进行了动态PK PET成像和结合潜能，计算了基底节和丘脑的配体-TSPO受体（由活化的小胶质细胞表达）结合的量度。与对照组相比，发现在PANDAS组中双侧尾状和双侧长形核以及仅在Tourette综合征组中双侧尾状核的结合电位值增加，表明潜在的激活的小胶质细胞介导的神经炎症。神经炎症的方式和程度的这些差异也表明PANDAS和Tourette综合征患者的病理生理病因可能存在差异。

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《Journal of child neurology》 |2015年第6期|共8页
作者
Kumar Ajay; Williams Mitchel T.; Chugani Harry T.;
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正文语种 eng
中图分类神经病学;
关键词
PET; PANDAS; Tourette syndrome; brain inflammation; basal ganglia;

机译：PET;PANDAS;Tourette综合征;脑炎;基底节;

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1. Evaluation of Basal Ganglia and Thalamic Inflammation in Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection and Tourette Syndrome: A Positron Emission Tomographic (PET) Study Using C-11-[R]-PK11195 [J] . Kumar Ajay, Williams Mitchel T., Chugani Harry T. Journal of child neurology . 2015,第6期

机译：儿童伴链球菌感染和抽动秽语综合症的小儿自身免疫性神经精神疾病的基底节和丘脑炎症的评估：正电子发射断层扫描（PET）研究使用C-11- [R] -PK11195
2. Clinical-Serological Characterization and Treatment Outcome of a Large Cohort of Italian Children with Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal Infection and Pediatric Acute Neuropsychiatric Syndrome [J] . Lepri Gemma, Rigante Donato, Randone Silvia Bellando, Journal of child and adolescent psychopharmacology . 2019,第8期

机译：临床 - 血清学特征及伴有细胞儿科儿童群体群体群体的治疗结果与链球菌感染与小儿急性神经精神综合征相关的儿科自身免疫性神经精神症
3. Evaluation of the Cunningham Panel (TM) in pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) and pediatric acute-onset neuropsychiatric syndrome (PANS): Changes in antineuronal antibody titers parallel changes in patient symptoms [J] . Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2020,第期

机译：与链球菌感染（熊猫）和小儿急性发作神经精神综合征（平底锅）相关的儿科自身免疫神经精神疾病评估：抗骨髓抗体的变化患者症状的平行变化
4. Gut Microbiota Profiling and Gut–Brain Crosstalk in Children Affected by Pediatric Acute-Onset Neuropsychiatric Syndrome and Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections [O] . Andrea Quagliariello, Federica Del Chierico, Alessandra Russo, -1

机译：小儿急性发作神经精神病综合症和与链球菌感染相关的小儿自身免疫性神经精神病患儿的肠道菌群分析和肠脑相声
5. PANDAS - Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection: constitui-se num transtorno clínico específico? PANDAS - Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infection: is it a specific clinical disorder? [O] . Harvey S Singer 2004

机译：paNDas - 与链球菌感染相关的小儿自身免疫性神经精神疾病：它是一种特殊的临床疾病吗？ paNDas - 与链球菌感染相关的儿科自身免疫性神经精神疾病：它是一种特殊的临床疾病吗？

Evaluation of Basal Ganglia and Thalamic Inflammation in Children With Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection and Tourette Syndrome: A Positron Emission Tomographic (PET) Study Using C-11-[R]-PK11195

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