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首页> 外文期刊>Journal of child psychology and psychiatry >Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse
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Rule breaking mediates the developmental association between GABRA2 and adolescent substance abuse

机译：违反规则调解了GABRA2与青少年滥用毒品之间的发展联系

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Background This study's primary aim was to examine age-specific associations between GABRA2, rule breaking, problematic alcohol use, and substance abuse symptomatology. The secondary aim was to examine the extent to which rule breaking mediates the GABRA2-substance abuse relationship. Methods A sample (n = 518) of primarily male (70.9%) and White (88.8%) adolescents from the Michigan Longitudinal Study was assessed from ages 11-18. Age-specific effects of GABRA2 on rule breaking, problematic alcohol use, and substance abuse symptomatology were examined using nested path models. The role of rule breaking as a mediator in the association between GABRA2 and substance abuse outcomes was tested using prospective cross-lagged path models. Results GABRA2 is significantly (p < 0.05) associated with rule breaking in mid- to late-adolescence, but not substance abuse symptomatology across adolescence. GABRA2 effects on problematic alcohol use and substance abuse symptomatology operate largely (45.3% and 71.1%, respectively, p < 0.05) via rule breaking in midadolescence. Conclusions GABRA2 represents an early risk factor for an externalizing pathway to the development of problematic alcohol and drug use.
机译：背景技术这项研究的主要目的是研究GABRA2，违反规则，有问题的饮酒和药物滥用症状之间的年龄相关性。第二个目的是检查规则在多大程度上介导了GABRA2物质滥用关系。方法从密歇根州纵向研究中抽取11例男性（70.9％）和白人（88.8％）青少年样本（n = 518）进行评估。使用嵌套路径模型检查了GABRA2对规则破坏，有问题的酒精使用和药物滥用症状的特定年龄效应。使用前瞻性交叉滞后路径模型测试了规则突破在GABRA2与药物滥用结果之间的关联中起中介作用。结果GABRA2与青春期中期至晚期的规则打破显着相关（p <0.05），但与整个青春期的药物滥用症状无关。 GABRA2对有问题的酒精使用和药物滥用症状的影响通过青春期中止规律的发挥很大作用（分别为45.3％和71.1％，p <0.05）。结论GABRA2是导致有问题的酒精和药物使用的外部化途径的早期危险因素。

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