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Commentary: Response to commentary by Rutter on Munafo et al. (2014)

机译:评论:对Rutter对Munafo等人评论的回应。 (2014年)

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Rutter's commentary (Rutter, 2014) on our article (Munafo et al., 2014) provides us the opportunity to clarify some issues that he (and therefore, we suspect, others) may have misunderstood.First, we do not dispute the existence of gene-environment (GxE) interactions. Rutter (2014) believes we are mounting a 'one-sided attack on GxE in relation to life events'. This is simply not so. We have no argument against the existence of GxE in the aggregate. Everyone is familiar with the idea that when two people encounter the same environmental stressor the results can be very different, and it makes sense to attribute this variation in part to differences in genetic makeup. Twin and family data provide formal tests of this idea, and confirm its importance (Cadoret, Yates, Troughton, Woodworth, & Stewart, 1995; Clon-inger, Sigvardsson, Bohman, & von Knorring, 1982; Kendler & Karkowski-Shuman, 1997). There are also convincing data from other species for the existence of GxE (Caligari & Mather, 1975; Crabbe, Wahlsten, & Dudek, 1999; Henderson, 1976; Valdar et al., 2006). Indeed we fully concur with the three points Rutter makes at the end of his commentary as the main messages for practitioners. But those points have nothing to do with the intent of our article.
机译:Rutter对我们文章(Munafo等人,2014)的评论(Rutter,2014)为我们提供了澄清一些他(因此我们怀疑其他)可能被误解的问题的机会。基因-环境(GxE)相互作用。 Rutter(2014)认为我们正在“对GxE进行与生命事件有关的单方面攻击”。事实并非如此。我们不反对在总体上存在GxE。每个人都熟悉这样的想法,即当两个人遇到相同的环境压力时,结果可能会非常不同,将这种差异部分归因于基因组成的差异是有意义的。双胞胎和家庭数据对这种想法进行了形式上的检验,并证实了其重要性(Cadoret,Yates,Troughton,Woodworth和Stewart,1995年; Clon-inger,Sigvardsson,Bohman和von Knorring,1982年; Kendler和Karkowski-Shuman,1997年。 )。其他物种也存在令人信服的关于GxE的数据(Caligari和Mather,1975; Crabbe,Wahlsten和Dudek,1999; Henderson,1976; Valdar等,2006)。的确,我们完全同意鲁特在他的评论结尾提出的三点观点,作为对从业者的主要信息。但是这些要点与本文的意图无关。

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