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首页> 外文期刊>Journal of child psychology and psychiatry >The temporal relation between depression and comorbid psychopathology in adolescents at varied risk for depression.
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The temporal relation between depression and comorbid psychopathology in adolescents at varied risk for depression.

机译：抑郁与各种抑郁风险的青少年抑郁和共病心理病理之间的时间关系。

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BACKGROUND: This study examined the temporal comorbidity of depressive disorders with anxiety, externalizing, and substance use disorders in adolescents who varied in risk for depression. METHODS: Participants were 240 adolescents and their mothers who had either a history of depression (high-risk, n = 185) or were lifetime-free of psychiatric disorders (low-risk, n = 55). Children (54.2% females) were first evaluated in 6th grade (mean age = 11.86, SD = .57) with the K-SADS-PL to assess current and lifetime diagnoses, and then annually through 12th grade with the A-LIFE to assess diagnoses since the previous evaluation. RESULTS: For girls, the rate of depression was high regardless of prior anxiety, whereas for boys, the odds that those with prior subthreshold anxiety would have subsequent subthreshold depression were 1.5 times those of boys with no prior subthreshold anxiety, controlling for risk. In addition, the odds that girls with prior substance use disorders would have a threshold depressive disorder subsequently were three times those of girls with no prior substance use disorders, controlling for risk. CONCLUSIONS: These results highlight the importance of early detection of various forms of psychopathology in youth who then can be targeted for intervention. The prospective paths to comorbidity differed by sex, thus suggesting that interventions need to be constructed with sensitivity to these distinct diagnostic trajectories.
机译：背景：这项研究检查了抑郁症风险不同的青少年的抑郁症与焦虑，外在性和物质使用障碍的时间合并症。方法：参与者为240名青少年，其母亲有抑郁史（高风险，n = 185）或终生没有精神疾病（低风险，n = 55）。首先对儿童（54.2％的女性）使用K-SADS-PL评估6年级（平均年龄= 11.86，SD = 0.57）以评估当前和终身诊断，然后每年通过12年级使用A-LIFE进行评估自上次评估以来进行诊断。结果：对于女孩而言，无论先前是否焦虑，抑郁症的发生率都很高，而对于男孩来说，具有先前阈下焦虑症的人会随后患有阈下抑郁症的几率是没有先前阈值焦虑的男孩的1.5倍，从而控制了风险。此外，具有先前物质使用障碍的女孩随后会有阈值抑郁症的几率是没有先前物质使用障碍的女孩的三倍，从而控制了风险。结论：这些结果强调了早期发现青年中各种形式的心理病理学的重要性，然后可以将其作为干预目标。性别导致合并症的前瞻性途径有所不同，因此表明在构建干预措施时必须对这些不同的诊断轨迹敏感。

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