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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction.
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Is all perfusion-weighted magnetic resonance imaging for stroke equal? The temporal evolution of multiple hemodynamic parameters after focal ischemia in rats correlated with evidence of infarction.

机译：中风的所有灌注加权磁共振成像是否相等？大鼠局灶性缺血后多个血液动力学参数的时间变化与梗死的证据有关。

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摘要

Although perfusion-weighted imaging techniques are increasingly used to study stroke, no particular hemodynamic variable has emerged as a standard marker for accumulated ischemic damage. To better characterize the hemodynamic signature of infarction. the authors have assessed the severity and temporal evolution of ischemic hemodynamics in a middle cerebral artery occlusion model in the rat. Cerebral blood flow (CBF) and total and microvascular cerebral blood volume (CBV) changes were measured with arterial spin labeling and steady-state susceptibility contrast magnetic resonance imaging (MRI), respectively, and analyzed in regions corresponding to infarcted and spared ipsilateral tissue, based on 2,3,5-triphenyltetrazolium chloride histology sections after 24 hours ischemia. Spin echo susceptibility contrast was used to measure microvascular-weighted CBV, which had a maximum sensitivity for vessels with radii between 4 and 30 microm. Serial measurements between 1 and 3 hours after occlusion showed no change in CBF (22 +/- 20% of contralateral, mean +/- SD) or in total CBV (78 +/- 13% of contralateral) in regions destined to infarct. However, microvascular CBV progressively declined from 72 +/- 5% to 64 +/- 11% (P < 0.01) during this same period. Microvascular CBV changes with time were entirely due to decreases in subcortical infarcted zones (from 73 +/- 9% to 57 +/- 14%. P < 0.001) without changes in the cortical infarcted territory. The hemodynamic variables showed differences in magnitude and temporal response, and these changes varied based on histologic outcome and brain architecture. Such factors should be considered when designing imaging studies for human stroke.
机译：尽管灌注加权成像技术已越来越多地用于研究卒中，但尚无特定的血液动力学变量作为累积缺血性损伤的标准指标。为了更好地表征梗死的血液动力学特征。作者已经评估了大鼠大脑中动脉闭塞模型中缺血性血液动力学的严重性和时间演变。分别通过动脉自旋标记和稳态药敏对比磁共振成像（MRI）测量脑血流量（CBF）和总和微血管脑血容量（CBV）的变化，并在与梗死和同侧组织相对应的区域中进行分析，根据缺血24小时后的2,3,5-三苯基四唑氯化物组织切片。自旋回波敏感性对比用于测量微血管加权CBV，它对半径在4到30微米之间的血管具有最大的敏感性。闭塞后1至3小时的连续测量结果显示，在梗塞区域，CBF（对侧22 +/- 20％，平均+/- SD）或总CBV（对侧78 +/- 13％）无变化。然而，在同一时期，微血管CBV逐渐从72 +/- 5％下降至64 +/- 11％（P <0.01）。微血管CBV随时间的变化完全是由于皮层下梗死区域的减少（从73 +/- 9％降低到57 +/- 14％。P <0.001）而皮层梗死区域没有变化。血液动力学变量显示出幅度和时间反应的差异，并且这些变化基于组织学结果和脑结构而变化。在设计针对人类中风的影像学研究时，应考虑这些因素。

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