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首页> 外文期刊>Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism >Functional brain mapping in freely moving rats during treadmill walking.
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Functional brain mapping in freely moving rats during treadmill walking.

机译：在跑步机上行走的自由移动大鼠的功能性脑图。

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摘要

A dilemma in functional neuroimaging is that immobilization of the subject, necessary to avoid movement artifact, extinguishes all but the simplest behaviors. Recently, we developed an implantable microbolus infusion pump (MIP) that allows bolus injection of radiotracers by remote activation in freely moving, nontethered animals. The MIP is examined as a tool for brain mapping in rats during a locomotor task. Cerebral blood flow-related tissue radioactivity (CBF-TR) was measured using [14C]-iodoantipyrine with an indicator-fractionation method, followed by autoradiography. Rats exposed to walking on a treadmill, compared to quiescent controls, showed increases in CBF-TR in motor circuits (primary motor cortex, dorsolateral striatum, ventrolateral thalamus, midline cerebellum, copula pyramis, paramedian lobule), in primary somatosensory cortex mapping the forelimbs, hindlimbs and trunk, as well as in secondary visual cortex. These results support the use of implantable pumps as adjunct tools for functional neuroimaging of behaviors that cannot be elicited in restrained or tethered animals.
机译：功能性神经影像学的一个难题是，避免运动伪影所必需的对象固定化将熄灭除最简单行为以外的所有行为。最近，我们开发了一种可植入的微丸式输注泵（MIP），该泵可通过远程激活在自由移动的非栓系动物中推注放射性示踪剂。在运动任务期间，将MIP检查为大鼠大脑作图的工具。使用[14C]-碘安替比林和指示剂分级法测量脑血流相关组织放射性（CBF-TR），然后进行放射自显影。与静止对照组相比，暴露于跑步机上行走的大鼠的初级躯体感觉皮层（测绘前肢）的运动回路（初级运动皮层，背外侧纹状体，腹侧丘脑，中线小脑，copula pyramis，旁中叶）的CBF-TR升高，后肢和躯干以及继发性视觉皮层。这些结果支持使用植入式泵作为辅助工具，对受约束或束缚的动物无法诱发的行为进行功能性神经影像学检查。

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